Do Coeliacs Suffer Badly From Sepsis?
As everybody seems to be getting this these days, I just had to ask Google AI the question in the title of this post.
This is the reply I received.
. Yes, individuals with celiac disease (CD) are at a modestly increased risk of developing sepsis, particularly pneumococcal sepsis, with studies showing a 1.6 to 2.6-fold higher risk of sepsis compared to the general population.
Here is a detailed breakdown of the relationship between celiac disease and sepsis:
Higher Risk of Specific Sepsis Types: The most significant risk is for pneumococcal sepsis (caused by Streptococcus pneumoniae), with some studies indicating a 2.5 to 3.9-fold increased risk.
Adult vs. Childhood Risk: The increased risk of sepsis is primarily, and in some studies solely, limited to individuals diagnosed with celiac disease in adulthood.
Cause – Hyposplenism: A major reason for this vulnerability is hyposplenism (reduced spleen function), which occurs in roughly 20% of patients with mild, controlled celiac disease, and up to 80% of those with untreated or complicated disease. The spleen is critical for fighting encapsulated bacteria like S. pneumoniae.
Other Potential Causes: Increased intestinal permeability (“leaky gut”) and malnutrition, which are associated with active celiac disease, may also contribute to a higher risk of infection.
Sepsis Outcome: While celiac patients are more likely to get sepsis, studies indicate that celiac disease does not significantly influence the survival or prognosis once a patient has developed sepsis.
Sepsis Outcome: While celiac patients are more likely to get sepsis, studies indicate that celiac disease does not significantly influence the survival or prognosis once a patient has developed sepsis.
Prevention: Because of the heightened risk, many guidelines recommend that individuals with celiac disease receive the pneumococcal vaccine, particularly if they have not already received it.
Conclusion: Coeliacs do not necessarily suffer “badly” in terms of worse survival rates from sepsis.
I can go along with that. Especially, as I have received the pneumococcal vaccine.
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The Anonymous Widower 
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