The Anonymous Widower

Blood Clot Risk Eight Times Higher From Covid Than AstraZeneca Vaccine, Study Finds

The title of this post, is the same as that of this article on The Telegraph.

This is the first two paragraphs.

The risk of a rare brain clot from coronavirus is approximately eight times greater the risk presented by the AstraZeneca jab, a University of Oxford study has found.

The research, which is yet to be peer-reviewed, and compared blood clot rates among 500,000 coronavirus patients with data from the roll-out of 34 million vaccine doses across Europe.

I will certainly be having my second AstraZeneca jab next Monday.

This press release on the Astra-Zeneca web site is entitled Oxford Phase III trials interim analysis results published in The Lancet.

This is an extract.

In addition to the Oxford led programme, AstraZeneca is conducting a large study in the US and globally. In total, Oxford University and AstraZeneca expect to enrol more than 60,000 participants globally.

The Telegraph article also says this.

The incidence of rates for cerebral venous thrombosis (CVT) – a rare blood clot on the brain – is 39 per million coronavirus patients, while it is five per million recipients of the AstraZeneca vaccine.

Note that five per million is 0.3 per 60,000.

Any participant, who got a blood clot in the AstraZeneca Phase III trial would have been a very unlucky person.

Those who say, that the AstraZeneca vaccine was rushed and that many more people should participated in the trials may have a point.

But countering that is my belief that data analysis has improved so much in the last twenty years that all the data on all the vaccines has been so thoroughly analysed by some of the best data analysts and analytic software, that most more common problems have been identified.

 

 

April 15, 2021 Posted by | Health | , , , , | 8 Comments

Covid-19, Coeliac Disease And Budesonide

I am coeliac and whenever a drug is shown to have positive effects against the Covids, I type its name into Dr. Google with coeliac disease.

With dexamethasone, I found it is used in some countries. as an alternative to a gluten-free diet.

Typically, these countries appear to be one with a Pop-A-Pill-For-Everything habit.

Budesonide appears to be used for Crohn’s disease, which is associated medically with coeliac disease.

As we keep hearing that the best way to fight the covids is with your immune system and coeliac disease is an autoimmune disease, is enough research being done as to the role o undiagnosed coeliac disease in this pandemic?

Coeliac UK are just advising Keep Calm and Carry On with the gluten-free diet!

April 13, 2021 Posted by | Health | , , , , | Leave a comment

Keep Calm And Carry On!

I saw a superb example of this on a bus today.

The bus was fairly crowded and I was standing.

A guy gets on and it was fairly obvious that he had no arms and from his age and appearance, it looked like he could have been a victim of thalidomide.

But no-one moved to offer him a seat!

So as the bus moved off, he calmly walked up the stairs to the top deck!

Shame on all those seat-sitters!

 

April 12, 2021 Posted by | Health, Transport | , | 2 Comments

Mayor Sadiq Khan Plans to Ban London Underground Gambling Ads

The title of this post is the same as that of this article on Gambling News.

It’s probably the right thing to do, but as fast food ads have been banned and others are probably to be banned as well, where does the Mayor think he is going to get the money to run Transport for London from?

As he is going to have an enquiry into the legalisation of cannabis, which I am against, as it ruins your immune system, I shall be voting for someone else.

April 8, 2021 Posted by | Health, Transport, World | , , , , , , | 3 Comments

Fall In Covid Infection Rates A Pleasant Surprise, Says Adviser

The title of this post, is the same as that of this article on The Times.

The adviser who is pleasantly surprised is Mike Tildesley of the University of Warwick.

I am not surprised that Mike Tildesley is pleasantly surprised.

I have successfully built mathematical models on computers for over fifty years, and since the pandemic started I have been pursuing my own mining of UK, WHO and Wikipedia data and peer-reviewed scientific papers from sources all over the world.

Several scientists have said, that an individual’s immune system is important, when it comes to fighting the covids.

I am coeliac on a long-term gluten-free diet and we as a group have a strong immune system. This probably explains, why we are 25 % less likely to suffer from cancer, than the general population. This fact is not from the Gwyneth Paltrow School of Quack Science, but from JVT’s alma mata; Nottingham University.

It has also been shown by the University of Padua, who followed a group of coeliacs on a long-term gluten-free diet, that they did very well during the first wave of the virus in Padua, with no serious cases reported.

Look at the figures for Cambodia, which has very low figures. They have had just 22 deaths and they have a fatality rate of 0.78% according to Wikipedia. Our rate on a similar basis is 2.94 %.

Can their gluten-free diet be the reason?

I’ve also heard verified stories of groups of immigrants doing well, as they have not been seduced by Western junk food and are sticking to traditional diets.

I think there are a large number of people out there like coeliacs on a long-term gluten-free diet, who because of their diet or lifestyle are not going to get the virus and act like moderators do in a nuclear power station to slow the reaction. So they are slowing the transmission of the virus. We have already seen how some religious groups and types of behaviour have accelerated the spread of the virus, so why can’t groups exist that slow the rate of spread?

Hence Mike Tildesley’s pleasant surprise!

I have not found any UK-based scientific research on how coeliacs are faring in the pandemic and the charity Coeliac-UK has said nothing except Keep Calm And Carry On!

Let’s hope the good scientists of Padua are continuing to follow their coeliacs through successive waves of the pandemic!

We need more research now!

April 6, 2021 Posted by | Health, Uncategorized | , , , | Leave a comment

UK Medicines Watchdog ‘Considers Limiting Use Of Oxford-AstraZeneca Coronavirus Vaccine In Young’

The title of this post, is the same as that of this article in The Times.

This is the first two paragraphs.

The medicines watchdog is considering restricting use of the Oxford-AstraZeneca coronavirus vaccine in younger people, it was reported last night.

Channel 4 News said sources had told it that the Medicines and Healthcare Products Regulatory Agency (MHRA) could decide as soon as today after concerns about very rare cases of blood clots potentially linked to the vaccine.

I’m, no medic, but I do find, I got a different reaction to the AstraZeneca vaccine to that of my friends.

But I am coeliac on a long-term gluten-free diet and have therefore got a strong immune system.

I believe my immune system gave the vaccine and its carrier a bit of a kicking.

But then it did that four months ago, with a pneumococcal vaccine.

There is a peer-reviewed Danish study, which I wrote about in A Danish Study On Links Between Coeliac Disease And Blood Clots.

I just wonder if there is a link in there somewhere.

All those, who have suffered blood clots after having the AstraZeneca vaccine should at least be tested for coeliac disease.

 

April 6, 2021 Posted by | Health | , , , , | Leave a comment

Have I Got Thrombophilia?

I was chatting on-line on The Times last night with a guy or even a girl, as their nick didn’t indicate gender.

I had said that a Danish study had shown that there were links between coeliac disease and blood clots. I wrote about this study in A Danish Study On Links Between Coeliac Disease And Blood Clots. Two of my on-line friends have since responded to that post with stories of coeliacs and blood-clots.

I got this reply from the person, I was chatting with.

There are some studies linking coeliac condition and the Factor V Leiden thrombophilia mutation. Several members of my family have (or had, since some have passed away) both conditions. I have the Factor V Leiden, as have both of my children. I do a lot of family history and have traced the Leiden mutation through triangulation of DNA matches and shared chromosome matches (via Family Tree DNA which goes into such detail) and I believe this is pointing to my Swedish ancestry.

I replied  and asked if the person had coeliac disease.

This was the reply.

I had some tests and a biopsy about 30 years ago to see if I had inherited the coeliac condition which had cut a swathe through my mother’s side of the family. It was negative, but I do suspect that I may have passed it on to my son. He’s not keen on getting tested although he did get a Leiden Factor V test and he is heterozygous for that. My mother, aunt, grandmother and cousins have coeliac and Leiden. Some have both and some have one or the other.

My mother was young enough to get proper advice, but my grandmother had a terrible time. She just literally faded away. Her treatment was eating raw liver and having injections of liver which left lumps under her skin. Awful.

I then looked up thrombophilia on Wikipedia. The picture of a red leg in the entry could have been of me, except that with me, It’s the other leg.

The NHS web site also gives useful information.

I need to see an expert urgently!

But at least, I’m already on the likely medication – Warfarin.

So it’s hopefully just a case of keep taking the tablets.

I must admit, I’m slightly annoyed with the medics. I have never been told, that there is a link between coeliac disease and blood clots, when evidence from the Danish peer-reviewed study and people I’ve met on-line clearly shows there is a link!

Given, all the arguments about the AstraZeneca vaccine and blood clots, more research needs to be done.

April 3, 2021 Posted by | Health | , , , , , , | Leave a comment

A Danish Study On Links Between Coeliac Disease And Blood Clots

I am a coeliac on a long-term gluten-free diet.

I am worried that the covids might prey on people like me, so I am researching hard to find out the truth.

Note that in much of Europe, North America and Australasia, coeliacs are at least 1-in-100 of the population and could be higher.

This morning I found on the Internet, a peer-reviewed Danish study which was entitled

Coeliac Disease And Risk Of Venous Thromboembolism: A Nationwide Population-Based Case-Control Study

The nation in the study was Denmark.

This was the introductory paragraph.

Patients with coeliac disease (CD) may be at increased risk of venous thromboembolism (VTE), i.e. deep vein thrombosis (DVT) and its complication pulmonary embolism (PE), because they are reported to have hyperhomocysteinaemia, low levels of K-vitamin-dependent anticoagulant proteins, and increased levels of thrombin-activatable fibrinolysis inhibitor.

One thing in this summary screams at me. The mention of vitamin-K!

Ten years ago, I had a serious stroke, that because of modern clot-busting drugs failed to kill me.

I am now on long-term Warfarin and know I have to eat a diet without Vitamin-K.

Given that in a nation like Germany with a population of eighty-three million, there could be nearly a million coeliacs, many of whom will be undiagnosed, this Danish study should be taken seriously, as it should be able to predict the number of clots down to coeliac disease in Germany. But I’m just an engineer and statistician and no medic. Although after the medical troubles of my family, I know a lot more medical knowledge than I did twenty years ago.

An article in The Times, also says that all but two who suffered clots after having the AstraZeneca vaccine were women.

It should be noted that the NHS states on its web site, that women are three times more likely to suffer coeliac disease than men.

I am absolutely certain, that more research needs to be done.

March 31, 2021 Posted by | Health | , , , , , | 6 Comments

Blood Clots In Young German Ladies After AstraZeneca Vaccine

There have been various reports that young ladies in Germany have suffered blood clots after having the AstraZeneca vaccine.

I am coeliac on a long-term gluten-free diet.

The UK, Ireland and Italy are generally fairly good at identifying coeliacs, as they suffer from so many side effects, one of which is strokes.

I had a stroke and a cardiologist thought it could have been because I wasn’t diagnosed until fifty, so my diet damaged my heart muscle causing atrial fibrillation.

My father, who I now believe was coeliac, died of a series of strokes.

I do wonder, if Germany doesn’t look for coeliacs, as they should, partly because it is a Jewish disease in their minds. Certainly finding gluten-free food in Germany can sometimes be difficult.

It should also be noted that the NHS says that there are three times as many coeliacs who are female.

Conclusion

This adds to the circumstantial evidence that coeliac disease is the alligator in the swamp of Covid-19.

 

March 31, 2021 Posted by | Health | , , , , , | 2 Comments

GSK To Manufacture 60m Doses Of Novavax Covid Vaccine In UK

The title of this post is the same as that as this article in the Financial Times.

As the Novavax Covid-19 vaccine is a two-dose vaccine, that is enough for thirty million people.

Wikipedia gives brief details of the the manufacturing of the vaccine for Canada and the UK in this section entitled Deployment.

On 2 February 2021, the Canadian Prime Minister Justin Trudeau announced that Canada has signed a tentative agreement for Novavax to produce millions of doses of its COVID-19 vaccine in Montreal, Canada, once it is approved for use by Health Canada, making it the first COVID-19 vaccine to be produced domestically.

On 29th March 2021, the UK government announced an order for 60 million doses of the Novax vaccine, which will be manufactured in the UK. FUJIFILM Diosynth Biotechnologies and GlaxoSmithKline will manufacture and fill the orders respectively.

This Google Map shows Barnard Castle in relation to Teesside.

Note.

  • The red arrow in the South-West corner of the map indicates the GSK factory at Barnard Castle.
  • Teesside is the estuary at the Eastern edge of the map.
  • FUJIFILM Diosynth Biotechnologies are located in Billingham, which is on the North bank of the Tees.

The two sites are under an hour apart.

This page on the UK Government web site gives details of the vaccines ordered.

  • Adenovirus – Oxford/AstraZeneca –  100 million – Approved and in deployment
    Adenovirus – Janssen – 30 million – Phase 3 trials
    mRNA – Pfizer/BioNTech – 40 million – Approved and in deployment
    mRNA – Moderna – 17 million – Approved
    Protein Adjuvant – GlaxoSmithKline/Sanofi Pasteur – 60 million – Phase 1/2 trials
    Protein Adjuvant – Novavax 60 million – Phase 3 trials
    Inactivated whole virus – Valneva – 60 million – Phase 1/2 trials

Note.

  1. Type, manufacturer, number and status are shown for each vaccine.
  2. This is a total of 567 million doses.

It looks to me, that backing four different technologies and seven different partnerships or companies was a successful strategy, as if the Novavax vaccine get approval, as serious commentators like Fergus Walsh of the BBC, think it will, picking four winners in a seven horse race.

GlaxoSmithKline appear to be a big loser in that they backed the French Sanofi Pasteur vaccine, which is still in Phase 1/2 trials. Wikipedia has a section entitled Deployment.

In July 2020, the UK government signed up for 60 million doses of a COVID-19 vaccine developed by GSK and Sanofi. It uses a recombinant protein-based technology from Sanofi and GSK’s pandemic technology. The companies claimed to be able to produce one billion doses, subject to successful trials and regulatory approval, during the first half of 2021. The company also agreed to a $2.1 billion deal with the United States to produce 100 million doses of the vaccine.

Someone appears to have lost billions.

I wonder though, if GSK had developed a plan to fill and finish the sixty million doses for the UK.

So have the fixers in the Joint Committee on Vaccination and Immunisation (JCVI) matched  FUJIFILM Diosynth Biotechnologies vaccine manufacturing to GSK’s fill and finish plan to give Novavax a 60 million dose capacity in the UK?

  • Both vaccines are of the same type, so can one fill and finish line handle both?
  • The Novavax vaccine was trialled in the UK.
  • Supplying Europe from Teesside would not be difficult.

Wikipedia seems to indicate, that Novavax like to spread production around. Spain, India and Poland are mentioned.

Conclusion

Every one of sixty million jabs helps.

President Macron was unavailable for comment.

March 29, 2021 Posted by | Health | , , , , | 1 Comment