The Anonymous Widower

Blood Clot Risk Eight Times Higher From Covid Than AstraZeneca Vaccine, Study Finds

The title of this post, is the same as that of this article on The Telegraph.

This is the first two paragraphs.

The risk of a rare brain clot from coronavirus is approximately eight times greater the risk presented by the AstraZeneca jab, a University of Oxford study has found.

The research, which is yet to be peer-reviewed, and compared blood clot rates among 500,000 coronavirus patients with data from the roll-out of 34 million vaccine doses across Europe.

I will certainly be having my second AstraZeneca jab next Monday.

This press release on the Astra-Zeneca web site is entitled Oxford Phase III trials interim analysis results published in The Lancet.

This is an extract.

In addition to the Oxford led programme, AstraZeneca is conducting a large study in the US and globally. In total, Oxford University and AstraZeneca expect to enrol more than 60,000 participants globally.

The Telegraph article also says this.

The incidence of rates for cerebral venous thrombosis (CVT) – a rare blood clot on the brain – is 39 per million coronavirus patients, while it is five per million recipients of the AstraZeneca vaccine.

Note that five per million is 0.3 per 60,000.

Any participant, who got a blood clot in the AstraZeneca Phase III trial would have been a very unlucky person.

Those who say, that the AstraZeneca vaccine was rushed and that many more people should participated in the trials may have a point.

But countering that is my belief that data analysis has improved so much in the last twenty years that all the data on all the vaccines has been so thoroughly analysed by some of the best data analysts and analytic software, that most more common problems have been identified.

 

 

April 15, 2021 Posted by | Health | , , , , | 8 Comments

Covid-19, Coeliac Disease And Budesonide

I am coeliac and whenever a drug is shown to have positive effects against the Covids, I type its name into Dr. Google with coeliac disease.

With dexamethasone, I found it is used in some countries. as an alternative to a gluten-free diet.

Typically, these countries appear to be one with a Pop-A-Pill-For-Everything habit.

Budesonide appears to be used for Crohn’s disease, which is associated medically with coeliac disease.

As we keep hearing that the best way to fight the covids is with your immune system and coeliac disease is an autoimmune disease, is enough research being done as to the role o undiagnosed coeliac disease in this pandemic?

Coeliac UK are just advising Keep Calm and Carry On with the gluten-free diet!

April 13, 2021 Posted by | Health | , , , , | Leave a comment

Have I Got Thrombophilia?

I was chatting on-line on The Times last night with a guy or even a girl, as their nick didn’t indicate gender.

I had said that a Danish study had shown that there were links between coeliac disease and blood clots. I wrote about this study in A Danish Study On Links Between Coeliac Disease And Blood Clots. Two of my on-line friends have since responded to that post with stories of coeliacs and blood-clots.

I got this reply from the person, I was chatting with.

There are some studies linking coeliac condition and the Factor V Leiden thrombophilia mutation. Several members of my family have (or had, since some have passed away) both conditions. I have the Factor V Leiden, as have both of my children. I do a lot of family history and have traced the Leiden mutation through triangulation of DNA matches and shared chromosome matches (via Family Tree DNA which goes into such detail) and I believe this is pointing to my Swedish ancestry.

I replied  and asked if the person had coeliac disease.

This was the reply.

I had some tests and a biopsy about 30 years ago to see if I had inherited the coeliac condition which had cut a swathe through my mother’s side of the family. It was negative, but I do suspect that I may have passed it on to my son. He’s not keen on getting tested although he did get a Leiden Factor V test and he is heterozygous for that. My mother, aunt, grandmother and cousins have coeliac and Leiden. Some have both and some have one or the other.

My mother was young enough to get proper advice, but my grandmother had a terrible time. She just literally faded away. Her treatment was eating raw liver and having injections of liver which left lumps under her skin. Awful.

I then looked up thrombophilia on Wikipedia. The picture of a red leg in the entry could have been of me, except that with me, It’s the other leg.

The NHS web site also gives useful information.

I need to see an expert urgently!

But at least, I’m already on the likely medication – Warfarin.

So it’s hopefully just a case of keep taking the tablets.

I must admit, I’m slightly annoyed with the medics. I have never been told, that there is a link between coeliac disease and blood clots, when evidence from the Danish peer-reviewed study and people I’ve met on-line clearly shows there is a link!

Given, all the arguments about the AstraZeneca vaccine and blood clots, more research needs to be done.

April 3, 2021 Posted by | Health | , , , , , , | Leave a comment

Blood Clots In Young German Ladies After AstraZeneca Vaccine

There have been various reports that young ladies in Germany have suffered blood clots after having the AstraZeneca vaccine.

I am coeliac on a long-term gluten-free diet.

The UK, Ireland and Italy are generally fairly good at identifying coeliacs, as they suffer from so many side effects, one of which is strokes.

I had a stroke and a cardiologist thought it could have been because I wasn’t diagnosed until fifty, so my diet damaged my heart muscle causing atrial fibrillation.

My father, who I now believe was coeliac, died of a series of strokes.

I do wonder, if Germany doesn’t look for coeliacs, as they should, partly because it is a Jewish disease in their minds. Certainly finding gluten-free food in Germany can sometimes be difficult.

It should also be noted that the NHS says that there are three times as many coeliacs who are female.

Conclusion

This adds to the circumstantial evidence that coeliac disease is the alligator in the swamp of Covid-19.

 

March 31, 2021 Posted by | Health | , , , , , | 2 Comments

University Of Oxford To Study Nasal Administration Of COVID-19 Vaccine

The title of this post, is the same as that of this article on the University of Oxford web site.

These two introductory paragraphs outline the structure of the tests.

The Phase I trial, which will enrol 30 healthy volunteers aged 18–40, will investigate the level of immune system responses generated by the vaccine using this delivery technique, as well as monitoring safety and for any adverse reactions.

All of the volunteers will receive the same vaccine that is currently being delivered by intramuscular injection as part of the national roll out of the ChAdOx1 nCoV-19 vaccine. The volunteers, who will be drawn from the local Oxford region, will be followed for a total of four months.

This is surely a very worthwhile study.

March 27, 2021 Posted by | Health | , , | 1 Comment

Blood Clots And Vaccines

I had a little bit of trouble with my Roche Coaguchek INR meter yesterday and had to phone Roche.

I indicated that I would soon be having my second AstraZeneca jab and measuring my INR before and after as a medical experiment.

I was then told that all vaccines can cause blood clots. That can’t be right?

But Roche should know!

March 26, 2021 Posted by | Health | , , , , | 5 Comments

Jaw Jaw Is Better Than War War!

There is an article in The Times today with a title of Britain Ready To Share Dutch-Made Vaccine With EU.

It talks of compromise and how Boris Johnson has effectively told his ministers to cool it.

I feel that Boris is right to seek a compromise. As Churchill said “Jaw, jaw is better than war-war!”

I wouldn’t be surprised that we have a lot to offer the EU about other things than making the vaccine.

Vaccination

There have been several examples published in this newspaper and other media outlets, about how we have squeezed extra doses out of the Pfizer vaccine and made sure we have potential recipients on hand, so that nothing goes to waste.

Perhaps we have a suitable brigadier, doctor, mandarin or project manager, who could put some drive and organisation into the EU’s flagging effort.

If it is a big loss of face to some EU politicians so be it.

AstraZeneca’s Problem

If AZ do have problem, it appears to be in the manufacture.

After all it is AZ’s first vaccine.

This surely, is a problem, that can be solved, even if it upsets AZ a bit on how it is done!

European Vaccine Reluctance

But I do think the EU’s vaccination is not helped by the population’s reluctance to have a jab.

We had Tom Jones and the US had Dolly Parton, amongst others who backed vaccinations.

Have stars of similar standing backed the vaccination in the EU?

Help From The Yanks

As usual, the Americans have arrived late to bolster the efforts.

Lets hope that their data published today persuades more EU citizens to take the jab and even one from the UK!

But surely any vaccine that gives you 100 % protection from severe disease, as the Yanks say that the AZ does, can’t be all bad!

Conclusion

I believe that as the UK and the EU share a common will to defeat the virus, that a good compromise can be developed over the next few days.

Let’s hope it goes better than the last time, we told the French what to do in a serious situation.

My father told me about Churchill’s dash to Paris in 1940 to offer union with France to try and save the country.

Read all about it in this article on the London School of Economics web site, which is entitled June 1940: Britain’s Forgotten Attempt To Build A European Union.

What Churchill Actually Said

In trying to find when Churchill used the title of this post, I found this page on the International Churchill Society web site, which is entitled Quotes Falsely Attributed To Winston Churchill.

The actual quote was “Meeting jaw to jaw is better than war” and it was misquoted later by Harold Macmillan.

Does meeting Zoom to Zoom count?

March 22, 2021 Posted by | Health | , , , , , , | 4 Comments

Is The UK Ready For A Tourist Boom This Summer?

Imagine one scenario, where we continue to vaccinate against Covid-19 and and large parts of the EU doesn’t, or at least goes slower and slower because of reluctance to use the AstraZeneca vaccine.

A simple mathematical model could mean that our number of cases drops like a stone and the anti-AZ countries suffer successive waves of the covids.

Where will vaccinated well-off North American, Antipodean and Far Eastern tourists want to go for their dose of European culture?

March 16, 2021 Posted by | Health, World | , , | 5 Comments

Fergus Walsh On The AstraZeneca Vaccine

I have just watching a ten-minute interview on BBC Breakfast with Fergus Walsh, who is the BBC’s Medical Editor.

If you are worried about Covid-19 vaccination and the AstraZeneca vaccine in particular, I suggest you find the interview on iPlayer. It took place at 0815.

He is undoubtedly well-connected to healthcare in the UK, as during the pandemic, he has had deep-access to doctors, researchers and patients, so anything he says, should surely be taken seriously.

Clots Caused By The AstraZeneca Vaccine

On this he said, it was at the same rate as the Pfizer vaccine. Now there’s a thing!

The rate of those, who broke their ankle after being vaccinated is also probably the same for both vaccines.

Fergus Has Had The AstraZeneca Vaccine

This happened on Sunday.

His endorsement of the vaccine, is probably as well-reasoned as anyone.

Conclusion

Why are politicians and others rubbishing the AstraZeneca vaccine, when respected agencies say there is no problem?

Is it just jealousy?

Given the success of the vaccine with AstraZeneca, I doubt Oxford will be looking for another partner.

March 16, 2021 Posted by | Health | , , , , , | 7 Comments

Long Covid And Coeliac Disease

I recently heard an interview with Adrian Chiles on Radio 5 about the so-called long covid

I am 73 and the more I read about Long Covid, the more I think I had something similar around 1958, when I had just started Minchenden Grammar School, where I missed most of the Spring Term. This was at the time of the 1957-8 flu pandemic., which killed between one and four million people worldwide.

This article on New Decoder is a personal memory of that pandemic, from an experienced journalist called Harvey Morris.

Last night, I was listening to another program about kids with long covid and they seemed to be describing how I felt all those years ago.

In 1997, at the age of fifty, I was diagnosed as a coeliac and have been gluten-free ever since. From friends and acquaintances, who are also coeliac on a long-term gluten-free diet, it appears that none of us have had a serious dose of the covids, including one who works in an office with several cases of Covid-19.

This observation has been backed-up by peer-reviewed research at the University of Padua, who followed a group of coeliacs on a long-term gluten-free diet through the first wave of the pandemic. None caught the virus.

It should also be noted that Joe West at the University of Nottingham, has shown that coeliacs on a long-term gluten-free diet are 25 % less likely to get cancer, so do we have a strong immune system, that gives us this protection against against both cancer and the covids.

Coeliac disease has been called the many-headed hydra by many doctors, so could it be an alligator in the swamp of Covid-19?

Research needs to be done!

But could it be that in 1958, my less than perfect immune system, because I was not diagnosed as a coeliac and was not on a gluten-free diet, had difficulty overcoming the flu at the time?

March 11, 2021 Posted by | Health | , , , , | Leave a comment