The Anonymous Widower

Warfarin And Lansoprazole

As I said in this post called Fasciitis In My Foot, I’ve got fasciitis in my right foot.

It wasn’t going away so my doctor prescribed 500mg. of Naproxen, night and morning, together with 30mg of Lansoprazole first thing, as I’m on Warfarin.

Normally, I take 4mg. of Warfarin a day, but when I am on other drugs, I test my INR regularly to make sure the drugs aren’t affecting my levels.

After a few days, my INR had gone up from its normal level of around 2.3-2.7 to around 4. So obviously, the new drug combination was raising my INR.

I solved the problem and brought the level of Warfarin down to 3mg. After a few days, my INR had returned to around 2.5.

That was a few weeks ago, but the fasciitis has refused to go away, so I am now back on the Naproxen/Lansoprazole combination, but with only 250mg. of the Naproxen.

My INR has jumped in the same way, but as before reducing the Warfarin dose to 3mg. has brought it back to normal.

I am drawn to two conclusions.

  • The Lansoprazole raises my INR,
  • Regular self-testing of your INR usually picks up problems.

This is very much a repeat of my experiences of taking Terbinafine, which I wrote about Interaction Between Warfarin And Terbinafine. Although that drug dropped the INR.

 

December 29, 2015 - Posted by | World | ,

1 Comment »

  1. Plantar Fasciitis is horrible, Neil and I have both had it. There are exercises on the internet which help, as does keeping the soles of your feet nice and warn, particularly in winter when floors are cold.

    I don’t know much about INR, but if I take NSAIDS, of which Naproxen is an example, I have to take Lansoprazole as well because one of the drugs I am on for something carries a tiny risk of intestinal bleeding, and the risk is greatly magnified if I add NAISDs into the equation. So it could be the NSAID which is raising your INR.

    Comment by nosnikrapzil | December 29, 2015 | Reply


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