How Is The Testing Of Babies In Italy For Coeliac Disease And Type 1 Diabetes Going?
I asked Google AI the question in the title of this post and received this reply.
Testing babies and children for coeliac disease and type 1 diabetes in Italy is progressing successfully, rooted in groundbreaking legislation. Italy is the first country to pass a national law (Law 130/2023) mandating mass screening for these conditions in children aged 1 to 17.
The pilot project, known as the D1Ce Screen, was rolled out in four key regions: Lombardia, Sardegna, Marche, and Campania. Testing is typically conducted at ages 2, 6, and 10.
Here is how the rollout is progressing based on interim data and reports:
Pilot Study Success: The screening involves a simple capillary (finger-prick) blood draw administered by primary care pediatricians. Participation in the initial phase was high, with over 75% of pediatricians and thousands of children successfully screened.
Higher-Than-Average Positivity Rates: Preliminary data revealed that approximately 2.8% to 2.9% of children tested positive for coeliac-specific antibodies—more than double the global average of 1% to 1.4%. Additionally, around 0.8% of children displayed markers for type 1 diabetes.
Early Detection: The pilot has proven highly effective at identifying asymptomatic or “silent” cases of both conditions early, which is vital for preventing acute complications like Diabetic Ketoacidosis (DKA) and avoiding the long-term impacts of undiagnosed coeliac disease.
High Public Acceptance: Surveys from the pilot regions indicate that more than 90% of parents are highly willing to have their children screened, though general public awareness of the national program is still being scaled up.
Following these successful pilot rollouts, the government continues to expand the screening program to ensure full, nationwide coverage to protect at-risk children before severe symptoms develop.
‘Breakthrough’ Blood Test For Sepsis To Save Lives
The title of this post, is the same as that of this article in the Sunday Times.
This is the sub-heading.
If the trial is a success it could allow speedy diagnosis for a condition that kills 48,000 people a year
These two paragraphs introduce the story.
A blood test is being trialled that can rapidly detect whether a patient has sepsis, in what could be a breakthrough for a condition that is notoriously difficult to diagnose.
Sepsis, which occurs when the immune system overreacts to an infection, kills about 48,000 people each year in the UK. More people die of it annually than of breast, prostate and bowel cancer put together. In severe cases, it can kill within hours.
A friend had sepsis and it nearly killed her. A test like this would probably have shortened her time in hospital.
I am coeliac and also a mathematical modeller and statistician.
- If you are coeliac and stick to your gluten-free diet, which now includes delicious real ale, you are 25 % less likely to suffer from cancer than the general population, according to research at Nottingham University.
- The reverse of this means that an undiagnosed coeliac living a rock ‘n’ roll lifestyle with lots of smoking, cannabis and a diet of gluten-rich junk food, you will have a higher chance of contracting cancer. Just as my undiagnosed coeliac son did, who died of pancreatic cancer at just 37.
- Coeliac testing was difficult until around 1960, when a method using endoscopy was developed. Then in the 1990s, a general test using blood was developed.
I have analysed NHS cancer statistics and there is a step-reduction in cancer rate for those born after 1960 and 1990.
A simple blood test for coeliac disease has found a lot more coeliacs and saved a lot of lives.
My analysis is shown in detail in Hospital Pioneers Cancer Service For Over 70s That Saves Lives And Money.
For that reason, I believe that this new sepsis test could also save a lot of lives.
Coeliac Disease And Risk Of Sepsis
The title of this section, is the same as that of this paper on the British Medical Journal.
This is the conclusion of the paper.
This study showed a modestly increased risk of sepsis in patients with coeliac disease with the highest risk for pneumococcal sepsis. This risk increase was limited to those with coeliac disease diagnosed in adulthood. Potential explanations include hyposplenism, increased mucosal permeability and an altered composition of the intestinal glycocalyx in individuals with coeliac disease.
Perhaps anyone, who goes into hospital, should also be tested for coeliac disease?
The Anonymous Widower 