The Anonymous Widower

Treatment Turns Up Heat On Tumours

The title of this post, is the same as that of an article in Tuesday’s Times.

It describes research at the Oxford Institute of Biomedical Engineering, where ultrasound is used to heat liver cancers to over 39.5 °C. The raised temperature then triggers the release of a drug.

The last quote of the report is from a researcher involved.

We can now begin to realise the promise of precision cancer medicine.

I’ve read about other ideas with the same outcome of precision.

I suspect my grandchildren will have a much higher chance of being cured of cancer.

July 12, 2018 Posted by | Health | , | Leave a comment

Angelina Jolie Gene Testing For All?

The title of this post is the same as this article on the BBC.

This is said.

Testing all women for the “Angelina Jolie gene”, even if not considered at risk, would prevent cancers, save lives and is cost effective, say doctors.

Having lived for forty years with my wife, who suffered breast cancer and then a few years later died from a squamous cell carcinoma of the heart, I know a lot about the emotional problems of cancer.

Many cancers and other diseases, like my coeliac disease, can be found in our genes.

Our youngest son died of pancreatic cancer, which was probably not helped by his smoking and poor eating and health habits.

If he had been a coeliac, which could have been likely because of my genes, that wouldn’t have helped either! But he wouldn’t be tested!

Speaking for myself, my life might have been very different, if I had been genetically tested as a child!

In the future, genetic testing will become much more the norm, as doctors, researchers, scientists and engineers will reduce the cost of doing a full genetic test.

The BBC article also says this.

The study, published in the Journal of the National Cancer Institute, estimated the impact of screening all 27 million women over 30 in the UK.

They said it would:

  • prevent 64,500 more breast cancers
  • prevent 17,500 more ovarian cancers
  • save 12,300 more lives

The study also said mass screening would be cost-effective for the health service.

But why stop at breast and ovarian cancer?

I feel strongly, that anybody likely to be a coeliac, should be tested at birth.

Keeping to a gluten-free diet, is getting easier every year and research at institutions like Nottingham University has shown, that coeliacs on a gluten-free diet are significantly less likely to get cancer, than the general population.

 

 

 

 

January 18, 2018 Posted by | Health | , , , | 2 Comments

Dame Sally Davies Puts The Boot In To Cancer

The lead item on BC Breakfast this morning is detailed in this article on the BBC web site entitled Chief medical officer calls for gene testing revolution.

Dame Sally Davies is very forthright in calling for gene testing to cease being a cottage industry and be nationalised with a large database of all information, to help in the treatment of cancer.

She said that spending the same amount of money on a national system, would bring better treatments to many more patients.

But she didn’t leave it at that and criticised doctors for not wanting a nation system and patients who don’t let their data be added to the national database.

I have been told by Liverpool University, that one of the reasons for their success with pancreatic cancer, is that they have an impressive database of cases from all over the world.

Those who refuse to allow their data to help others, need to be persuaded in the strongest possible way.

July 4, 2017 Posted by | Health | | 1 Comment

It’s Cancer Good News Time Again!

These articles have appeared on the BBC in recent days.

Last June this story on the BBC web site entitled ‘Major Win’ In Pancreatic Cancer Fight was published.

It is not unexpected at this time of year, as a big cancer conference takes place around now every year.

There is also another pattern that seems to be happening in all the good news.

Research is key and often the research has been funded by Cancer Research UK and performed in our Universities.

Some techniques like innovative routes of attacking the cancer cells and understanding the action of existing drugs better seem to be more common.

We’ll never win totally against cancer, but we’ll certainly win a few skirmishes.

We should all do our bit for not ourselves, by not smoking!

June 3, 2017 Posted by | Health | , | Leave a comment

Remembering A Relative Or Friend

In seven days it would have been my late wife’s sixty-eighth birthday.

C gave her body for medical research and we had a private cremation a year or so later.

In her memory and also in that of my son, who died of pancreatic cancer in 2010, I helped to fund in a very small way some research into the disease at my mine and my late wife’s university of Liverpool.

I wrote about the research in There’s More To Liverpool Than Football And The Beatles!

In some ways, the successful outcome of the research, gave me an enormous lift and now when I think of my son, I sometimes think, that others will hopefully not have to go through, what he and his family did!

Serious research can do that!

So I got to thinking, that perhaps when a friend or relative dies, we should start a fund and give the money to an appropriate charity, that funds research into whatever was the cause of their death.

My funding of Liverpool University’s Pancreatic Cancer research that came about because I asked Alumni Relations at the University to suggest a suitable research project for my donation.

The Devil must have blessed the donation and the research produced a positive result.

But not everyone can be so lucky.

So why not, when someone close to you dies, collect an appropriate amount of money and ask the major charity or perhaps as I did, your old University to find a project to help fund?

I would think that it could be best to go to a central charity like Cancer Research UK or the British Heart Foundation, as they might now something that was very suitable, based in a University of research institution convenient to where you live!

I feel that selecting a well-run and well-respected central charity is that they know the ropes and that the world is littered with charitable failures, set up by individuals with the best of intentions.

August 19, 2016 Posted by | Health | , , , | 1 Comment

Liverpool University Strikes Again!

In the latest alumni newsletter from my old University, there is a link to this page on the University web site, which is entitled Cancer Drug Trial Success.

This is said.

The University of Liverpool has led a successful trial of a drug trial aimed at developing new therapeutic approaches to cancer.

The trial (APR-246) aimed to test the effects of a novel compound on a specific protein, p53, found to be mutated in more than 50% of all cancers.

The p53 gene is from a class of genes called tumour suppressors which are mutated in all cases of one form of ovarian cancer (high grade serous), but have proved difficult to target in the past.

This research was also done in the Institute of Translational Medicine, where the pancreatic cancer research I wrote about in There’s More To Liverpool Than Football And The Beatles! was carried out.

It certainly would appear that something is being done correctly!

August 8, 2016 Posted by | Health | , | Leave a comment

My Mid-Life Crisis

They were talking midlife crises on Radio 5 yesterday, so I sent in a text, which was broadcast.

My mid-life crisis was caused by the death of my wife and our youngest son to cancer smd then my stroke at 63. But I survived and raised money for pancreatic research at mine and my late wife’s University of Liverpool. Yesterday, I visited the unit and left feeling that there is now some hope for people suffering from this awful cancer. My mid-life crisis seemed to be receding as I took the train home.

Hopefully, life can only get better!

Incidentally, since my visit to Liverpool, I’ve spoken to three or four people, who have been affected by pancreatic cancer and I hope my attitude has given them a bit of strength to face the future.

July 27, 2016 Posted by | Health | , , , | Leave a comment

When Will The United States Realise That Guns Kill People?

On the wall of my office, there used to be a picture of my wife presenting a racing trophy to a racehorse trainer.

Both are now dead.

We fight cancer with common sense and all the tools that science has given us.

Isn’t it about time, that common sense is applied to the problem of guns in the United States and other countries where they are responsible for a high murder rate?

June 12, 2016 Posted by | World | , , , | 1 Comment

Why I Support Cancer Research UK

In yesterday’s post; There’s More To Liverpool Than Football And The Beatles, I talked about how researchers at Liverpool University had developed a better prostate cancer treatment. I posted this from an An article in The Guardian.

The ESPAC trials, which began publishing findings in 2004, showed that chemotherapy with gemcitabine brings five-year survival up to 15-17%, doubling the rate of survival with surgery alone. The latest research, presented at theAmerican Society of Clinical Oncology meeting in Chicago, showed the two-drug combination nearly doubles the survival rate again to 29%.

It showed, said Neoptolemos, that chemotherapy does work in pancreatic cancer, even though most attention in cancer research is now focused onimmunotherapy, and precision or targeted medicine.

But the trial would not have happened without funding from the charity CancerResearch UK (CRUK), because both drugs are old and off-patent, meaning they can be made by any generic drug manufacturer and are consequently cheap. Drug companies would not foot the bill for such a trial because the profits to be made are small.

“This is an academic-led presentation,” said Neoptolemos. “This shows the enormous value of CRUK. Without them, none of this would have happened. There is a lot of pressure [on doctors] to do drug company trials because you get £2,000 to £3,000 a patient. For something like this, you don’t get anything. It has been quite tough to do.”

That is a very strong endorsement of Cancer Research UK.

Today, there is this story on the BBC web site, which is entitled Bowel cancer: Stents ‘may prevent need for colostomy bags’. This is said.

Bowel cancer patients may avoid the need for colostomy bags if they are first treated by having an expandable tube inserted at the site of their blockage, cancer doctors have said.

The new approach, presented at the world’s biggest cancer conference, showed that the tube, or stent, cut the risk of complications from surgery.

The trial took place at Central Manchester University Hospitals! And who funded the trial? Cancer Research UK!

So I shall keep supporting the work of Cancer Research UK!

June 5, 2016 Posted by | Health | , , | 2 Comments

Why The London Tramlink Should Be Extended To The Royal Marsden Hospital

One of my Google Alerts picked up this article in the Sutton Guardian entitled Bunker for breakthrough cancer therapy machine could fit 24 Routemaster buses.

It is about the creation of a concrete bunker at the Royal Marsden Hospital to house a cross between an MR Linac machin which is decribed like this here on the Institute for Cancer Research web site.

The MR Linac combines two technologies – an MRI scanner and a linear accelerator – to precisely locate tumours, tailor the shape of X-ray beams in real time, and accurately deliver doses of radiation even to moving tumours.

All this leads to more and more patients going to the Royal Marsden Hospital in Sutton to get treatment.

As many will not be in the best of health and would not relish a stressful journey, surely now is the time to build extension A of the London Tramlink to Sutton and the Hospital. This map shows the current proposal.

St. Helier Tramlink

St. Helier Tramlink

The Royal Marsden Hospital is South of Sutton.

As Sutton is a Thameslink station, this Tramlink extension will give access to the Royal Marsden from a large area of London and the South East.

October 4, 2015 Posted by | Health, Travel | , , , | 2 Comments