Are There People, Who Have Very Leaky Skin And Consequently Lose A lot Of Fluids And Have To Drink A Lot. Do Some Become Alcoholics?
I’m actually asking this question for my paternal grandfather, who died on the 25 Jun 1929.
- I obviously never met him.
- My father told me he was a chronic alcoholic.
- My father was upset about his father’s drinking and did his utmost to ensure I didn’t follow his father’s example.
- At no time in my life, have I been drunk day after day, like my paternal grandfather.
- My father set me an excellent example on drinking and I tried to follow his lead.
The question in the title of this post, is based on a composite person of myself and my paternal grandfather.
- In My Strange Skin, I describe the unusual properties of my skin, which often causes medical staff to have a good laugh.
- My previous excellent GP would always take my blood and, never needed a plaster and always had a big smile on his face afterwards.
- I am coeliac and I am fairly certain my father was, but was my paternal grandfather?
I asked Google AI the question in the title of this post and received this AI Overview.
While people generally lose some fluid through normal sweating, there are specific medical conditions that cause excessive fluid loss through the skin, primarily genetic disorders affecting the skin’s barrier function.
One prominent example is Netherton Syndrome, a rare genetic condition that results in a defective skin barrier . People with this condition experience:
- Excessive Trans-Epidermal Water Loss (TEWL): Their skin loses moisture much faster than a healthy person’s skin.
- Dehydration Risk: This requires them to constantly monitor hydration levels and drink plenty of fluids to compensate for the continuous loss.
- Another condition is epidermolysis bullosa (EB), a group of genetic diseases that make the skin very fragile and blister easily. The open wounds and blisters also lead to significant fluid loss, increasing the risk of dehydration and infection.
Note that my skin doesn’t have open wounds and blisters and generally heals well and quickly if I cut myself. My late wife would compliment me on my skin and say it was very much like that of our son, who died of pancreatic cancer.
The second part of the question—whether these individuals become alcoholics as a consequence of their condition—is more complex. There is no evidence in medical literature or research to suggest a direct causal link between having a “leaky skin” condition (which necessitates high fluid intake) and the development of alcoholism.
- Fluid management vs. alcohol consumption: Individuals with these conditions need to consume water, milk, or specific electrolyte-balancing fluids.Alcohol has a diuretic effect, meaning it would actually worsen dehydration and be counterproductive to their necessary fluid management.
- Risk factors for alcoholism: Alcoholism is a complex condition influenced by a combination of genetic, psychological, social, and environmental factors, not by the physiological need to consume large volumes of non-alcoholic fluids.
In summary, certain conditions do cause significant fluid loss through the skin requiring high fluid intake, but this physiological need is managed with appropriate hydration (water, electrolytes), and does not lead to alcoholism.
I will now use, what intelligence I have and my observations of my own body to build on these results.
I Have Very Dry Eyes
I had my first eye test in a shed in a friend’s back garden. But the guy who did it, had been the Senior Eye Surgeon in Ipswich Hospital, so he had practiced at a high level and had a lot of experience.
- During the tests, he remarked to me, that I had the driest eyes he’d ever encountered.
- Afterwards, I got bought the glasses from Boots in Ipswich.
- They were fine and served me well for a number of years.
- A few years later, I was involved in a research project at Moorfields Eye Hospital, where members of the public gave their opinion on new eye testing machines that the NHS might use.
- Moorfields said my eyes were indeed very dry.
- The last professional to comment on my eyes was an opthalmist in Vision Express, who suggested that I bathe my eyes in clean, hot water every morning.
- A couple of days later I saw my GP on another matter and he gave the same advice.
My eyes have been a lot more comfortable since.I also have not had to go to a hospital to have a wayward fly taken out of my eyes, which must have happened perhaps four or five times before.
Are Very Dry Eyes A Sign Of Netherton Syndrome?
I asked Google AI, this question and received this answer.
Yes, very dry eyes can be an associated sign or complication of Netherton Syndrome (NS) and other forms of ichthyosis. The underlying skin barrier defect in NS can lead to various eye problems.
- Ectropion: In some cases, the chronic skin inflammation and tightness can cause ectropion, where the eyelids evert (turn outwards) and do not close properly. This prevents the eyelids from adequately covering and protecting the eyeballs, leading to severe exposure and dryness.
- Ichthyosis and Meibomian Gland Dysfunction: Netherton syndrome is a type of ichthyosis, which is characterized by dry, scaly skin. Patients with ichthyosis often have meibomian gland dysfunction (MGD), where the glands that produce the oily layer of the tear film don’t function correctly. This results in the tear film evaporating too quickly, causing evaporative dry eye.
- Corneal Complications: Chronic dry eye can lead to more severe issues like keratitis (inflammation of the cornea) or punctate epithelial erosions, which are painful and can affect eyesight.
It looks like Google AI is thinking in the right direction.
Are Very Dry Eyes A Sign Of Excessive Trans-Epidermal Water Loss?
I asked Google AI, this question and received this answer.
Yes, very dry eyes are associated with increased trans-epidermal water loss (TEWL) from the ocular surface. Studies have shown that individuals with dry eye disease (DED) have significantly higher ocular TEWL values compared to healthy individuals.
- Tear Evaporation: TEWL from the ocular area is used as a measure of tear evaporation. Excessive tear evaporation is one of the two main causes of DED and leads to a condition called evaporative dry eye (EDE).
- Compromised Barrier: The tear film has a protective lipid (oil) layer that acts as a barrier to prevent excessive evaporation of the aqueous (water) layer of the tear film. A compromised or deficient lipid layer, often caused by meibomian gland dysfunction, results in increased tear evaporation/TEWL.
- Aqueous-Deficient Dry Eye: Even in cases of aqueous-deficient dry eye (ADDE), where the primary problem is low tear production, patients can still experience increased tear evaporation and higher TEWL, indicating a complex overlap between the two main types of DED.
- Ocular Surface Inflammation: Excessive tear evaporation leads to tear hyperosmolarity (increased salt concentration), which is a key factor in causing inflammation and damage to the ocular surface, contributing to the symptoms of very dry eyes.
Are Very Dry Eyes A Sign Of Epidermolysis Bullosa
I didn’t ask Google AI, as it was obvious, when I looked at the pictures on the Internet, that I hadn’t got epidermolysis bullosa.
A Picture Is Worth A Thousand Words
Looking at the pictures of the various causes of dry eye, I came to the conclusion meibomian gland dysfunction could be the cause of my very dry eyes.
Can Meibomian Gland Dysfunction Cause Very Dry Eyes?
I asked Google AI, this question and received this answer.
- Tear Film Breakdown: When glands are blocked (MGD), they produce poor quality or insufficient oil, causing the tear film to break down rapidly.
- Evaporation: Without enough oil, tears evaporate too fast, leaving the eye’s surface exposed, dry, and irritated.
- Gritty, itchy, or burning sensation
- Redness and inflammation
- Watery eyes (paradoxically, due to instability)
- Sticky eyelids or discharge, especially in the morning
- Blurred vision, particularly at the end of the day
Do Hot Baths Help Uncomplicated Pancolonic Diverticular Disease?
I asked Google AI the question in the title of this post and received this answer.
Yes, hot baths and warm compresses may help to relieve the pain and muscle spasms associated with uncomplicated pancolonic diverticular disease, or diverticulitis, by relaxing abdominal muscles and improving blood circulation to the area. While there’s no evidence that heat cures diverticulitis, it is a simple, non-invasive way to soothe cramps, and your doctor may recommend it alongside other self-care measures.
When my late wife was alive, this was our morning routine.
- I would bring her a cup of hot Marmite and often I would run her a hot bath.
- C liked her baths very hot.
- After she had got dressed and gone off to work, I would often use her hot bath to have a good soak.
- Both of us, weren’t too keen on showers, but we never complained about water usage or the other’s cleanliness.
These days, I generally have a hot bath every day.
Can Uncomplicated Pancolonic Diverticular Disease Make You Feel Listless?
I asked Google AI the question in the title of this post and received this answer.
Yes, while uncomplicated diverticular disease often causes no symptoms, some people can experience listlessness (fatigue or general unwellness) from either the inflammation of diverticulitis or chronic symptoms like bloating and pain. Fatigue can stem from infection, inflammation, disrupted sleep, nutritional deficiencies, or the impact of chronic pain. If you’re experiencing persistent listlessness, it’s important to speak with a healthcare provider, especially if it’s accompanied by other symptoms like fever, severe abdominal pain, or changes in bowel habits.
I have certainly suffered from listlessness over the years, but until recently, I have always had a good woman ; my mother or C, to perk me up.
Study Highlights Increased Risk Of Second Cancers Among Breast Cancer Survivors
The title of this post, is the same as that of this news story from the Cambridge University.
This is the sub-heading.
Survivors of breast cancer are at significantly higher risk of developing second cancers, including endometrial and ovarian cancer for women and prostate cancer for men, according to new research studying data from almost 600,000 patients in England.
These are the first three paragraphs of the story.
For the first time, the research has shown that this risk is higher in people living in areas of greater socioeconomic deprivation.
Breast cancer is the most commonly diagnosed cancer in the UK. Around 56,000 people in the UK are diagnosed each year, the vast majority (over 99%) of whom are women. Improvements in earlier diagnosis and in treatments mean that five year survival rates have been increasing over time, reaching 87% by 2017 in England.
People who survive breast cancer are at risk of second primary cancer, but until now the exact risk has been unclear. Previously published research suggested that women and men who survive breast cancer are at a 24% and 27% greater risk of a non-breast second primary cancer than the wider population respectively. There have been also suggestions that second primary cancer risks differ by the age at breast cancer diagnosis.
I have a few thoughts.
The Data
The story says this about the data.
To provide more accurate estimates, a team led by researchers at the University of Cambridge analysed data from over 580,000 female and over 3,500 male breast cancer survivors diagnosed between 1995 and 2019 using the National Cancer Registration Dataset. The results of their analysis are published today in Lancet Regional Health – Europe.
A large number of cases were analysed and with these types of analysis, more is definitely better.
I would hope that this study will be repeated in a few years, when more data is available.
The Death Of My Wife
This happened to my late wife.
At about 55 in 2004, my wife developed breast cancer. Strangely, it was in the same position, where a car air-bag had bruised her breast, when it went off in an accident, a few years before.
Chemotherapy was recommended and she tried one round at home, but she couldn’t get on with it.
So she eventually had a long course of radiotherapy in Harley Street going up every day on the train. She was also doing as many court cases as she could to pay for it all.
It appeared everything had worked well and in the Autumn of 2007, she was given the all clear for the breast cancer.
But in October 2007, she was diagnosed with a squamous cell carcinoma of the heart.
She died in December 2007 at just 59.
My wife’s second cancer and her death seems to fit the pattern of the patients in the news story.
My Wife’s Genetic Background
This is rather bare, as she was adopted. Although, I do have her plaits from, when the cut them off at 18, as she’d kept them and I found them after she died.
But she didn’t come from a deprived background.
I Am Coeliac
If I have one regret, it’s that I didn’t encourage her to go gluten-free after the first cancer.
It might have boosted her immune system to help.
Conclusion
Anybody, who has breast cancer must beware a second attack of cancer.
Uf it can kill my fit 59-year-old wife, it can kill anyone.
The Great Cadaver Shortage: Inside Doctors’ Latest Crisis
The title of this post, is the same as that of this article in The Times.
This is the sub-heading.
Faced with a dwindling supply of fresh bodies to train on, British medical schools are having to turn to America’s low-regulation ‘tissue trade’. Would you donate yours, asks Jenny Kleeman
My late wife, C; left her body to medical science and I may well choose to do the same with my body.
She left her body to St. George’s Medical School, mainly because one of her friend’s mother had done the same and there had been no problems.
Looking back on the nearly twenty years since she died, I remember a few months after her death, there was a multi-faith joint Memorial Service in Southwark Cathedral for all those who’d donated their bodies, in the previous year.
None of my family were or are religious, but I’m sure the service helped our grieving, as it was a very moving and inclusive service, that was the Church of England at its best, with assistance from other faiths.
Perhaps if donation were to be linked to support for the bereaved and perhaps a Memorial Service, this might increase the level of donations.
What sort of affect would it create in a city like Liverpool, if the yearly service alternated around the major places of worship in the city and was well-covered on local media?
The Anonymous Widower 