‘Biggest Breakthrough’ On Pancreatic Cancer Is On The Horizon As Scientists Hail Two-In-One Teatment That Could Even CURE The Disease
The title of this post, is the same as that of this article on the Daily Mail.
These three paragraphs give an introduction to the research.
Scientists are on the cusp of the ‘biggest ever’ breakthrough in the treatment of pancreatic cancer.
UK researchers have developed a two-in-one treatment that could dramatically improve survival and even cure the disease, which is one of the deadliest cancers.
Survival rates for pancreatic cancer have barely improved in the last 50 years and it has the worst prognosis of any common cancer.
It is a state, that you don’t want to go near.
This is the heart of the new two-in-one treatment.
One of the treatments is immunotherapy, whereby a drug fires up the immune system to fight the cancer.
The drug is a checkpoint inhibitor, which means it blocks proteins that stop the immune system from attacking cancer cells. It has had stunning results against some types of cancer.
But pancreatic cancer tumours have a thick outer layer which stops the drug in its tracks.
The second treatment, known as high intensity focused ultrasound (HIFU), involves blasting the tumour with pulses of sound waves.
This creates tiny bubbles in the cells, which bounce around with such force that they puncture holes in the protective barrier – allowing the immunotherapy drug to get to work.
I find it strange that I when I wrote Glencore & Strategic Partner Britishvolt Strengthen Relationship And Agree To Build Battery Recycling Ecosystem In The UK, I found that a similar technique is being investigated by the Faraday Institute in the recycling of lithium-ion batteries.
In this article on the BBC, which is entitled As The World looks To Electrify Vehicles And Store Renewable Power, One Giant Challenge Looms: What Will Happen To All The Old Lithium Batteries?, I found this paragraph.
The team has also found a way to achieve direct recycling of the anode and cathode using an ultrasonic probe, “like what the dentist uses to clean your teeth,” he explains. “It focuses ultrasound on a surface which creates tiny bubbles that implode and blast the coating off the surface.” This process avoids having to shred the battery parts, which can make recovering them exceedingly difficult.
Umpteen million tiny bubbles can’t be wrong! It sounds to me that engineers from the Faraday Institute and Medics from the Institute of Cancer Research have been imbibing pints of the thinking man’s liqueur; real ale in a serious meeting in a pub.
But if it works don’t knock it! Just use the technique on your project to remove an awkward coating.
My son, who died of pancreatic cancer was a coeliac like me, but he had never been tested and as he was a sound engineer in the music business, he lived on a diet of Subways, cigarettes and high strength cannabis.
I asked the Professor at Liverpool University’s Pancreatic Cancer Research Unit, if this had contributed to his death and he nodded.
But my son certainly, didn’t have my strong immune system, which is because I’m coeliac and have been gluten-free for nearly thirty years. I know it is strong, as it gave the first dose of the AstraZeneca vaccine a good kicking. But by the time I got the second dose, it had worked out it was a friend, so I got no reaction.
I have three questions.
What is the hard skin of the pancreatic cancer made from?
Do all cancers have hard skins?
When patients are given immunotherapy drugs, do they go gluten-free for a Tesco effect (Every little helps!)?
Talgo To Begin Fuel Cell Loco Trials
The title of this post, is the same as that of this article on Railway Gazette.
These are the first two paragraphs.
Trials are to begin shortly with the TPH2 fuel cell test locomotive developed by Talgo as part of its hydrogen traction programme. This forms part of a low-carbon research and development strategy which is being supported by a green hydrogen supply alliance and financing from the European Investment Bank.
The TPH2 loco has been produced by fitting fuel cells and traction batteries to the Travca L-9202 ‘Virgen del Buen Camino’ prototype multi-system and variable gauge locomotive which was built by Talgo in 2005.
This page on the Talgo web site describes the Travca locomotive like this.
Travca: Traction Without Borders
Travca is a locomotive that stops at nothing; not at different power supplies, track gauges nor signalling systems all of which makes Travca Talgo’s most advanced development in the field of traction.
This is the specification of the electric locomotive from the Talgo web site.
- Operating speed – Up to 250km/h (passenger version)
- Configuration – Bo-Bo
- Track gauge (mm) -1435-1668
- Length (m) – 19400
- Bodyshell width (mm) – 2950
- Unladen weight (tonnes) – 72 (passenger version)
- Number of axles – 4
- Power – 2,400 kW (25kV, 50Hz) / 2,000kW (3kV dc)
- Brakes – Regenerative, rheostatic and air brakes
Notes.
- It is a variable-gauge and variable-voltage locomotive.
- 1435 mm is standard gauge
- It is lighter and wider than a Class 90 locomotive.
It does seem to be the basis of a very useful locomotive.
This article on Railway News is entitled University Of Extremadura To Work With Talgo On Its Hydrogen Train, says this about the test train.
During the first stage of the hydrogen train project, Talgo is developing the necessary engineering for the assembly and commissioning of hydrogen traction in a test train. The train will comprise a Talgo Travca MS locomotive, which can change gauges and run under different electrification systems, and five Talgo hauled cars that will house the hydrogen fuel cell system. One of the cars will be a laboratory car.
This would appear to be an experimental train with the hydrogen power station in four of the coaches.
It also appears that Extremadura is developing a hydrogen infrastructure.
Applications In The UK
The obvious application in the UK, is as a Class 66 diesel locomotive replacement, for some of the light to medium duties.
The Class 66 locomotives have a power of 2400 kW, which could be within the range of the Talgo locomotive.
In LNER Seeks 10 More Bi-Modes, I speculated that Talgo, with all their experience of high speed trains might like to bid for the extra ten trains, that LNER requires.
They could be ideal to allow electric trains to run between London and Aberdeen and Inverness.
- The Travca locomotive running on electricity could certainly handle 140 mph between London and Edinburgh.
- The power requirements North of Edinburgh would be less, as speeds would be lower.
- Ranges on hydrogen would be under two hundred miles.
It would be a flagship service for both LNER and Talgo.
Guided Beam Treatment Is Extending Life For Patients With Pancreatic Cancer
The title of this post, is the same as that of this article in The Times.
This is the first two paragraphs.
The lives of patients with inoperable pancreatic cancer could be extended by years with a “game-changing” radiation treatment that uses MRI technology to accurately target tumours.
A study has found that MRI-guided radiotherapy almost doubles the median survival rate in cases of inoperable pancreatic cancer compared with conventional treatment that uses CT scans.
It looks like a case of the more accurately you target your weapon, the more effective it is.
A few years before she died of a much more serious but totally unrelated cancer, my wife suffered from breast cancer.
- The cancer wasn’t massive and it had probably been caused by a severe bruise, where she had been struck by an exploding air-bag in a car accident.
- She also had a top-class surgeon in Cambridge. Barristers always get the best, as local chambers always know those who are being sued for malpractice.
- To make sure, the cancer didn’t return she had targeted radiotherapy in Harley Street daily for four or five weeks.
- She even travelled up to London from Suffolk daily on the train, often fitting Court appearances around the appointments.
- A few weeks before she died, she was checked for breast cancer and pronounced clear.
The treatment had worked and it convinced me of the value of targeted radiotherapy.
I must say, it increases my optimism, that pancreatic cancer might be one cancer, where we can at least prolong life in many cases.
My optimism about pancreatic cancer probably started , after the results of the research to which I added funding in a small way were published. I wrote about them in There’s More To Liverpool Than Football And The Beatles!.
The Anonymous Widower 