Are There People, Who Have Very Leaky Skin And Consequently Lose A lot Of Fluids And Have To Drink A Lot. Do Some Become Alcoholics?
I’m actually asking this question for my paternal grandfather, who died on the 25 Jun 1929.
- I obviously never met him.
- My father told me he was a chronic alcoholic.
- My father was upset about his father’s drinking and did his utmost to ensure I didn’t follow his father’s example.
- At no time in my life, have I been drunk day after day, like my paternal grandfather.
- My father set me an excellent example on drinking and I tried to follow his lead.
The question in the title of this post, is based on a composite person of myself and my paternal grandfather.
- In My Strange Skin, I describe the unusual properties of my skin, which often causes medical staff to have a good laugh.
- My previous excellent GP would always take my blood and, never needed a plaster and always had a big smile on his face afterwards.
- I am coeliac and I am fairly certain my father was, but was my paternal grandfather?
I asked Google AI the question in the title of this post and received this AI Overview.
While people generally lose some fluid through normal sweating, there are specific medical conditions that cause excessive fluid loss through the skin, primarily genetic disorders affecting the skin’s barrier function.
One prominent example is Netherton Syndrome, a rare genetic condition that results in a defective skin barrier . People with this condition experience:
- Excessive Trans-Epidermal Water Loss (TEWL): Their skin loses moisture much faster than a healthy person’s skin.
- Dehydration Risk: This requires them to constantly monitor hydration levels and drink plenty of fluids to compensate for the continuous loss.
- Another condition is epidermolysis bullosa (EB), a group of genetic diseases that make the skin very fragile and blister easily. The open wounds and blisters also lead to significant fluid loss, increasing the risk of dehydration and infection.
Note that my skin doesn’t have open wounds and blisters and generally heals well and quickly if I cut myself. My late wife would compliment me on my skin and say it was very much like that of our son, who died of pancreatic cancer.
The second part of the question—whether these individuals become alcoholics as a consequence of their condition—is more complex. There is no evidence in medical literature or research to suggest a direct causal link between having a “leaky skin” condition (which necessitates high fluid intake) and the development of alcoholism.
- Fluid management vs. alcohol consumption: Individuals with these conditions need to consume water, milk, or specific electrolyte-balancing fluids.Alcohol has a diuretic effect, meaning it would actually worsen dehydration and be counterproductive to their necessary fluid management.
- Risk factors for alcoholism: Alcoholism is a complex condition influenced by a combination of genetic, psychological, social, and environmental factors, not by the physiological need to consume large volumes of non-alcoholic fluids.
In summary, certain conditions do cause significant fluid loss through the skin requiring high fluid intake, but this physiological need is managed with appropriate hydration (water, electrolytes), and does not lead to alcoholism.
I will now use, what intelligence I have and my observations of my own body to build on these results.
I Have Very Dry Eyes
I had my first eye test in a shed in a friend’s back garden. But the guy who did it, had been the Senior Eye Surgeon in Ipswich Hospital, so he had practiced at a high level and had a lot of experience.
- During the tests, he remarked to me, that I had the driest eyes he’d ever encountered.
- Afterwards, I got bought the glasses from Boots in Ipswich.
- They were fine and served me well for a number of years.
- A few years later, I was involved in a research project at Moorfields Eye Hospital, where members of the public gave their opinion on new eye testing machines that the NHS might use.
- Moorfields said my eyes were indeed very dry.
- The last professional to comment on my eyes was an opthalmist in Vision Express, who suggested that I bathe my eyes in clean, hot water every morning.
- A couple of days later I saw my GP on another matter and he gave the same advice.
My eyes have been a lot more comfortable since.I also have not had to go to a hospital to have a wayward fly taken out of my eyes, which must have happened perhaps four or five times before.
Are Very Dry Eyes A Sign Of Netherton Syndrome?
I asked Google AI, this question and received this answer.
Yes, very dry eyes can be an associated sign or complication of Netherton Syndrome (NS) and other forms of ichthyosis. The underlying skin barrier defect in NS can lead to various eye problems.
- Ectropion: In some cases, the chronic skin inflammation and tightness can cause ectropion, where the eyelids evert (turn outwards) and do not close properly. This prevents the eyelids from adequately covering and protecting the eyeballs, leading to severe exposure and dryness.
- Ichthyosis and Meibomian Gland Dysfunction: Netherton syndrome is a type of ichthyosis, which is characterized by dry, scaly skin. Patients with ichthyosis often have meibomian gland dysfunction (MGD), where the glands that produce the oily layer of the tear film don’t function correctly. This results in the tear film evaporating too quickly, causing evaporative dry eye.
- Corneal Complications: Chronic dry eye can lead to more severe issues like keratitis (inflammation of the cornea) or punctate epithelial erosions, which are painful and can affect eyesight.
It looks like Google AI is thinking in the right direction.
Are Very Dry Eyes A Sign Of Excessive Trans-Epidermal Water Loss?
I asked Google AI, this question and received this answer.
Yes, very dry eyes are associated with increased trans-epidermal water loss (TEWL) from the ocular surface. Studies have shown that individuals with dry eye disease (DED) have significantly higher ocular TEWL values compared to healthy individuals.
- Tear Evaporation: TEWL from the ocular area is used as a measure of tear evaporation. Excessive tear evaporation is one of the two main causes of DED and leads to a condition called evaporative dry eye (EDE).
- Compromised Barrier: The tear film has a protective lipid (oil) layer that acts as a barrier to prevent excessive evaporation of the aqueous (water) layer of the tear film. A compromised or deficient lipid layer, often caused by meibomian gland dysfunction, results in increased tear evaporation/TEWL.
- Aqueous-Deficient Dry Eye: Even in cases of aqueous-deficient dry eye (ADDE), where the primary problem is low tear production, patients can still experience increased tear evaporation and higher TEWL, indicating a complex overlap between the two main types of DED.
- Ocular Surface Inflammation: Excessive tear evaporation leads to tear hyperosmolarity (increased salt concentration), which is a key factor in causing inflammation and damage to the ocular surface, contributing to the symptoms of very dry eyes.
Are Very Dry Eyes A Sign Of Epidermolysis Bullosa
I didn’t ask Google AI, as it was obvious, when I looked at the pictures on the Internet, that I hadn’t got epidermolysis bullosa.
A Picture Is Worth A Thousand Words
Looking at the pictures of the various causes of dry eye, I came to the conclusion meibomian gland dysfunction could be the cause of my very dry eyes.
Can Meibomian Gland Dysfunction Cause Very Dry Eyes?
I asked Google AI, this question and received this answer.
- Tear Film Breakdown: When glands are blocked (MGD), they produce poor quality or insufficient oil, causing the tear film to break down rapidly.
- Evaporation: Without enough oil, tears evaporate too fast, leaving the eye’s surface exposed, dry, and irritated.
- Gritty, itchy, or burning sensation
- Redness and inflammation
- Watery eyes (paradoxically, due to instability)
- Sticky eyelids or discharge, especially in the morning
- Blurred vision, particularly at the end of the day
10 Exciting New Train Journeys Coming To The UK In 2026
The title of this post, is the same as that of this article in The Telegraph.
The journeys are.
South Wales Metro (The ‘Welsh Tube’)
Effectively, what the Welsh have done is turn the railways radiating from Cardiff into the sort of metro that Birmingham, Glasgow, Liverpool and Tyne-Tees have created over the last few decades.
- They are replacing a large proportion of the rolling stock, with new electric or hybrid-electric trains and tram-trains.
- Some of the lines are notably scenic.
- Some new stations have been added.
- There are attractions to visit.
- A Day Ranger ticket is available.
A few times in the past few years, when I feel I need some fresh air, I’ve taken a train to Cardiff, bought a Day Ranger and climbed a few hills in a train, as in my seventies, I’m too old to walk up.
I wouldn’t be surprised that the forthcoming Leeds Metro borrows heavily from ideas developed on the South Wales Metro.
London To Stirling
Stirling is one of those towns and cities, like Barrow-in-Furness, Blackpool, Shrewsbury and a few others, that Virgin and Avanti West Coast seem reluctant to serve.
I feel by choosing Stirling for a service, Lumo have just done the obvious.
- The route is fully-electrified.
- Stops will be Milton Keynes, Nuneaton, Crewe, Preston, Carlisle, Lockerbie, Motherwell, Whifflet, Greenfaulds, and Larbert.
- There will be four trains per day.
- The initial trains will be Class 222 trains.
- The electric Class 803 trains are on order.
- Hitachi are developing battery-electric trains for Lumo on the East Coast to be able to use the diversion via Lincoln, which would probably reach Perth.
- Car-hire companies will do well in Stirling.
- Stirling has onward train connections to Aberdeen, Dundee, Inverness, Montrose, Perth and Stonehaven.
- I wouldn’t be surprised to see FirstGroup, who are Lumo’s parent or another coach company, creating a hydrogen-powered coach network for the North of Scotland.
- The service will start in May 2026.
That really shows how railways can be used to boost growth. But will the SNP get the message?
I will use this service to have a few days in Stirling and explore the Southern part of the Scottish Highlands by train.
Caledonian Sleeper from Birmingham
This looks to be obvious addition to the Caledonian Sleeper.
The Telegraph says this.
The joys of the Caledonian Sleeper to Scotland, well known to travellers from London, are to be extended for the first time to those wanting to alight at Birmingham International. This change – the biggest in the Caledonian Sleeper schedule for 30 years – will mean that greeting the dawn approaching places as far flung as Fort William, Aberdeen and Inverness will be a far more realistic prospect for fans of this form of travel who live in the Midlands.
Note.
- The Birmingham stop will be at International not New Street.
- The service starts on January 16.
- Only the Highlander will stop at Birmingham International.
It seems to be a well-thought out simple addition to the service.
Newquay And Falmouth
The Telegraph says this.
Exciting news for fans of Cornwall where a new direct service linking the north and south coasts this year will make travelling by train between the key towns of Newquay and Falmouth considerably easier. The improvement to the current journey, frequently involving multiple changes and lasting two and half hours, will start with an increase in services between Newquay and Par in the spring and, by the end of the year, the commencement of the direct link all the way through to Falmouth.
Note.
The project is named the Mid Cornwall Metro.
The project has cost £57 million.
The route will be Newquay and Falmouth Docks via Quintrell Down, St. Columb Road, Roche, Bugle, Luxulyan, Par, St. Austell, Truro, Perranwell, Penryn, Penmere and Falmouth Town.
For more information, see midcornwallmetro.com
The journey time between Newquay and Falmouth will be cut by forty-five minutes.
I am sure that there are other rail systems in the UK, Ireland and in the wider world, that could benefit from a
High Speed Sonnet (Weardale To Stratford-upon-Avon)
The Telegraph says this.
And now for something completely different: a one-off charter train from the dales of County Durham to Stratford-upon-Avon, the heart of Shakespeare country. This journey, dubbed the “High Speed Sonnet”, comes as part of the 50th anniversary celebrations of the introduction of the legendary InterCity 125 high speed trains, one of which will be deployed on the run from Stanhope to the birthplace of the bard.
This train journey, although it is probably very nice is not really my scene.
- I don’t have a partner.
- I don’t live near to Weardale or Stratford-on-Avon.
- As I’m coeliac and low alcohol, I’m not really keen on gourmet dining events.
But the train is an Intercity 125, so some might like to take a ride.
For more details see excursionsbyrail.co.uk
West Highland Line, Scotland
The Telegraph says this.
A journey along the West Highland line, the most scenic stretch of track in Britain, and a visit to the Royal waiting room used by Queen Victoria during visits to Balmoral are two of the highlights of a new tour for 2026, offered by small group Scotland and UK specialists McKinlay Kidd.
Similar comments to the previous journey apply, except that it is West Scotland.
But the train is steam-hauled over the Glenfinnan Viaduct of Harry Potter fame, so some might like to take a ride.
For more details see mckinlaykidd.com
Mid Wales Explorer
The Telegraph says this.
Another new tour for 2026, this one run by The Railway Touring Company, has as its focus the central part of Wales. Highlights include a journey along the Welsh Highland line on the “Harbourmaster”, shorter trips on the celebrated little railways of Llangollen, Bala Lake, Talyllyn, Vale of Rheidol and Welshpool, and a narrowboat ride across world heritage Pontcysyllte Aqueduct located 38 metres above the River Dee. Tidy.
I might go on this one if the date of June 10th fits.
For more details see railwaytouring.net
Newcastle And Brighton
The Telegraph says this.
How about this for a tantalising prospect – a direct service between Newcastle and Brighton calling at York, Sheffield, Birmingham New Street, Oxford, Reading, and Gatwick Airport – with no need to change trains in London? This is the new route proposed by open-access operator Grand Central (part of Arriva UK Trains) and currently awaiting approval from the Office of Rail and Road.
All going well, services – five trains each way daily – should start by the end of the year. A potential game changer and, following the commencement of the direct link between Seaham and London in December 2025, a further example of Grand Central’s drive to connect underserved communities.
For more details see grandcentralrail.com
London And Cleethorpes
The Telegraph says this.
Another Grand Central proposal that whets the appetite is the application to run direct services (for the first time since 1992) between London and the Lincolnshire seaside town of Cleethorpes. While not without its critics, Cleethorpes is an old-school British resort with pier, promenade and the Cleethorpes Coast Light (miniature) Railway service. If approved, four services a day would be up and running by the end of 2026; additional stops would include Doncaster, Scunthorpe, Grimsby, Thorne South, Crowle and Althorpe.
For more details see grandcentralrail.com
Note.
Althorpe is not to be confused with the burial place of Princess Di.
In Lunch On The Pier In Cleethorpes, I wrote about excellent gluten-free fish and chips on the pier.
Champagne Moments On The Northern Belle
The Telegraph says this.
The late Queen Mother famously enjoyed G&Ts while seated in carriages which now form part of the the Northern Belle. This in mind, she would likely have approved of the latest innovation on one of Britain’s plushest trains: the addition of a “Krug class”, which includes one bottle of Krug Grande Cuvée Champagne per couple, to enjoy over a multi-course meal and seating in Duart (formerly a carriage on The Royal Train) or Glamis, named after the Queen Mother’s childhood home.
The train operates a number of day trips on scenic routes to landmark cities such as York, Edinburgh and Bath, and to colourful events such as the RHS Chelsea Flower Show.
For more details see 95pp; northernbelle.co.uk
The Anonymous Widower 