Covid: Genes Hold Clues To Why Some People Get Severely Ill
The title of this post, is the same as that of this article on the BBC.
This is the opening paragraph.
Why some people with coronavirus have no symptoms and others get extremely ill is one of the pandemic’s biggest puzzles.
It is now less of a puzzle, thanks to research led by the University of Edinburgh.
These paragraphs explain the methodology.
Scientists looked at the DNA of patients in more than 200 intensive care units in UK hospitals.
They scanned each person’s genes, which contain the instructions for every biological process – including how to fight a virus.
Their genomes were then compared with the DNA of healthy people to pinpoint any genetic differences, and a number were found – the first in a gene called TYK2.
One of the other genes mentioned is IFNAR2, where this was said.
Variations in a gene called IFNAR2 were also identified in the intensive care patients.
IFNAR2 is linked to a potent anti-viral molecule called interferon, which helps to kick-start the immune system as soon as an infection is detected.
It’s thought that producing too little interferon can give the virus an early advantage, allowing it to quickly replicate, leading to more severe disease.
I know a bit about interferon and I must admit I’ve made a bit of profit on shares in Synairgen, which are linking interferon with an inhaler.
I then typed “coeliac disease and interferon” into Google and found this article on The Lancet, which is entitled Onset Of Coeliac Disease and Interferon Treatment.
My medical knowledge is very limited, but it does appear that if you are coeliac on a gluten-free diet, you don’t get any problems, with interferon.
The plot thickens!
Not for nothing, do some doctors call coeliac disease, the Many-Headed Hydra.
Why I’ll Delay Having The Coronavirus Vaccine
The vaccines are coming for the covids, but I won’t be having a jab, if one is offered to me, in the first round. I may not be offered one, as I am only 73 and in good health.
But there are many out there, who need the vaccine more than I do, who will be given lower priority than myself.
So I’ll wait!
I am also a diagnosed coeliac on a gluten-free diet and my statistical researches and news reports, show that communities and groups with high levels of undiagnosed coeliacs have suffered badly from the covids.
These communities and groups include.
- Anybody born before 1960, as there was no test for coeliac disease in children before then.
- Ashkenazi Jews. My coeliac genes come from an ancestor in this group.
- Irish
- Caribbean. West Africans have a tendency to coeliac disease and what better way to bring it out, than starve them on slave ships and feed them on only bread and water.
I have also found a research paper, that shows, that India could now experience a coeliac disease epidemic, caused by modern strains of wheat. See Coeliac Disease: Can We Avert The Impending Epidemic In India?
Coeliacs on a gluten-free diet, are an interesting group, in that according to peer-reviewed research by Joe West of Nottingham University, they are 25 % less likely to suffer from cancer.
How can one disease protect you from another?
My coeliac disease was indicated by low-levels of B12, as gluten was damaging my gut and stopping it absorbing vital vitamins. By removing the gluten from my diet, my B12 levels returned to normal.
So it’s the diet that protects my health.
If you think, you are coeliac, don’t be put off by horror stores of multiple endoscopies and the difficulty of sticking to a gluten-free diet. I may have been one of the first individuals tested, by the current genetic method, which is now used by most GPs. A blood sample is sent off for a test and that is generally all that is done in most cases. I heard in 48 hours.
So why is it beneficial in the case of cancer?
It can only be, that with all those vitamins, coeliacs on a gluten-free diet have a very healthy immune system.
So does, this immune system, help protect coeliacs from the covids?
Until proven otherwise, my statistical research, thinks it does!
So I believe, that I can afford to wait.
Has Good Project Management Helped The UK Get The Vaccine Early?
Professor Van-Tam, this morning on BBC Breakfast, praised the planning of the drug companies and the various health bodies in charge of certification of the vaccines.
As someone, who was at the heart of the Project Management Revolution in the 1970s and 1980s, this cheers me.
Looking back, my biggest contribution to project management, was to prove that you didn’t need to use a large mainframe computer and software would work on a small desk-sized machine and ultimately on a personal computer, thus bringing project management to everyone.
Second Time Around For A Lockdown
What is different this time around, is that I’ve had three months practice and I believed it would come, so I stocked up with essentials.
My Dalstonista grandmother regretted in the Great War, she didn’t stock up, so wasn’t caught out in the Second, with a hundredweight of both jam and sugar in the cellar.
My essentials are a bit different.
- Adnams Beer – 0.5 % alcohol.
- Tins of sardines in tomato.
- Gluten-free pasta
- Muesli
- Pots of porridge.
- Pots of M & S luxury honey & ginger yoghurt. For adding to fruit, muesli and as a pasta sauce.
- Ready meals in the freezer.
I would assume, I can get gluten-free bread, bananas, milk and eggs, when I need them.
Gloria Gaynor’s song is in my brain.
Le Pain Quotidien Has Reopened
This is good for coeliacs, as they do reasonable gluten-free food.
I can also get a 73 bus directly to Goodge Street station, where there is a particularly good Le Pain Quotidien, close to a Marks & Spencer food store and a Rymans.
What more could I want?
Note.
- I caught the bus close to my house and sat in the tail-gunner’s seat.
- The 73 bus has now been rerouted down Tottenham Court Road.
- The green-glazed building is University College Hospital. I now have a direct bus to the hospital, where I sometimes go for appointments.
- Tottenham Court Road is now two-way for buses, cyclists and taxis.
I shall use that Le Pain Quotidien more often.
Screening For Coeliac Disease
People ask me if they should be screened for coeliac disease.
This page on Coeliac UK is entitled Screening For Coeliac Disease.
They quote this advice from NICE.
NICE has advised that people with close relatives (for example father, mother, son, daughter, brother, sister) are at increased risk of coeliac disease and so should be considered for screening. This would involve having a blood test in the first instance.
That sounds fairly sensible to me.
Coronavirus: Can I Be Infected By Touching Surfaces?
The title of this post is the same as that of an article on The Sunday Times.
The article is worth reading.
These two paragraphs some up the latest thoughts on infection from surfaces.
Monica Gandhi, a professor of medicine at the University of California, San Francisco, told the US science website Nautilus that there had been “a lot of fear” at the beginning of the pandemic about transmission of the virus if people touched their faces after contact with metal, plastic or other contaminated surfaces, collectively known to scientists as fomites.
Yet the evidence suggests that the virus on most surfaces is not strong enough to make people ill. “It’s not through surfaces,” she added. “It’s from being close to someone spewing virus from their nose and mouth, without in most cases knowing they are doing so.”
I travel around the Underground a lot and I’m always masked, when I enter stations and usually use the hand-sanitisers, at least once on a trip. Most in London, seem to be acting similarly.
There has been no scares about using the Underground because of high-rates of the covids in recent months, that I can find.
More importantly, under a sub-title of Why Are Young Women The Targets Now?, this is the first paragraph.
The disease that ravaged care homes and turned the elderly into hermits for much of the spring has taken aim at different targets this autumn. Public Health England’s most recent statistics show that the 20-29 age group has had the most new cases since the end of June, followed closely by the 30-39 age group. In both those groups, more women are being infected than men.
This is paragraph is from the NHS web site.
Reported cases of coeliac disease are around 3 times higher in women than men. It can develop at any age, although symptoms are most likely to develop: during early childhood – between 8 and 12 months old, although it may take several years before a correct diagnosis is made.
Could this paragraph partly explain, the fact that women in their twenties and thirties are suffering from the covids?
Coeliac disease affects one in fifty of the population.
As a coeliac, it’s no hard task to stick to a gluten-free diet.
And I get the bonus of being 25 % less likely to suffer from cancer, according to peer-reviewed research from Nottingham University.
The Small Sign That Means So Much To A Coeliac
I’ve bought Marks & Spencer’s mackerel pate for any years.
It’s the first time, I’ve noticed the packaging has the gluten-free symbol.
More please! My eyesight needs glasses to read the allergies!
Thoughts On COVID-19 On Merseyside
Merseyside is in trouble with the covids.
These are the number of lab confirmed cases per 100,000 population for local authorities in the area, as of the 1st October 2020.
- Halton – 1108.1
- Knowsley – 1388
- Liverpool – 1244.5
- Sefton – 1037.6
- St. Helens – 1230.4
- Wirral – 1185.5
My London Borough of Hackney, which is demographically, a bit like poorer parts of Liverpool, has a rate of 524.3.
But the gold standard to my mind is Cambridge, which has a rate of only 380.6.
Oxford, which is a very similar city to Cambridge has a much higher rate of 799.5,
Why Is Cambridge Doing So Well?
I was diagnosed as a coeliac at Addenbrooke’s Hospital in Cambridge, twenty-three years ago.
According to my consultant in the City at the time, Cambridge has a VERY high level of diagnosed coeliacs.
He told me, that he had more coeliac patients, than any other gastroenterologist in the UK.
So why is the number of coeliacs so high in Cambridge?
I feel it is because Cambridge had a Whack-a-Coeliac policy in the 1990s, where they attempted to diagnose as many coeliacs as they could find.
I was certainly diagnosed at that time and judging by the speed they did the initial diagnosis, I suspect, they were using one of the first genetic tests. They were also doing endoscopies without anaesthetic to increase throughput!
Coeliacs, Cancer And The Covids
Diagnosed coeliacs on a gluten-free diet have a strong immune system, which helps protect them from cancer, as has been shown by Joe West at Nottingham University.
I should also add, that none of my coeliac acquaintances have had a severe dose of the covids.
So does our stronger immune systems give us protection from the covids?
This could explain, why an area like Cambridge has a lower level of the covids than Oxford.
Why Is Merseyside In Trouble?
The Irish, because of historic famine, have higher levels of coeliac disease.
Comedians from the City have joked about Liverpool being the capital of Ireland for decades.
Could it be that there is a high percentage of undiagnosed coeliacs on Merseyside?
If this is true, could these undiagnosed coeliacs, with poorer immune systems, be easy pickings for the covids?
Conclusion
These actions should be taken.
- Merseyside needs a Whack-a-Coeliac policy, if it doesn’t have one! It would certainly, improve cancer rates!
- Every in-patient with the covids, should be given a quick blood test for coeliac disease.
- Other research needs to be done to find out the any link between coeliac disease and the covids!
Not for nothing is coeliac disease regularly called the Many-Headed Hydra by some doctors and researchers.
Suzie’s Cup Of Joy
It must be very difficult for small cafes in this pandemic, but Suzie’s Cup of Joy in Cleethorpes seemed to be managing. They were certainly doing all the right things.
I had a gluten-free breakfast there on Wednesday.
I would have sat outside, but it was rather breezy.
Lunch At Cafe Piazza In The Hays Galleria
I had a gluten-free lunch in Caffe Piazza in the Hays Galleria near to London Bridge station.
I only had a baked potato and chilli con carne with a glass of wine, but that was all I needed.
I’ll definitely go back again.
The Anonymous Widower 