How To Protect The UK Population From Future Pandemics
The Times today has an article, which is entitled Flu Jab: Single-Shot Vaccine ‘Within Five Years’ Could Stop Future Pandemic.
This is the introductory paragraph of The Times article.
A single-shot vaccine against flu that would provide a lifetime of protection even against future mutations could be available in “five years or less”, scientists have said after making a breakthrough.
The article is very much a must-read, but I believe if used alongside a simple proven medical test, it could be even more effective.
Since 1997, when I was diagnosed as coeliac and started eating gluten-free food exclusively, I have never had a dose of flu.
I may have had one very mild dose of Covid-19, but I have never had a serious dose.
Research At The University Of Padua
This partial immunity to Covid-19 has been shown in a peer-reviewed scientific paper, by the University of Padua in Italy.
I discuss the Padua research in Risk Of COVID-19 In Celiac Disease Patients.
Mathematical Modelling Of Pandemics
As a control engineer, mathematical modeller and statistician, I believe that our herd immunity to future pandemics could be increased, if all new entries to the UK population, like babies and migrants, were tested for coeliac disease.
These days the coeliac test is just a blood test, that costs just a few pounds and I believe that a high percentage of gluten-free coeliacs in the UK population, because of their low susceptibility to flu pandemics, would slow the spread of the pandemic.
In a nuclear reactor non-radioactive carbon rods are often used to control the speed of the reaction.
I believe that non-susceptible coeliacs on gluten-free diets would perform the same function in the UK population.
Should Diagnosed Coeliacs Be Forced To Be Gluten-Free?
I would not force coeliacs to go gluten-free.
They would have to face up to the consequences, if they didn’t.
My son was an undiagnosed coeliac, who refused to get tested.
He died at 37 of pancreatic cancer, as his immune system was useless.
Coeliac disease and a gluten-free diet is a good wingman, but undiagnosed it can kill you!
Why Should Migrants Be Tested?
I hope they are, as some might have something nasty.
But if everyone was tested for a wide range of health and genetic conditions, could it act as a deterrent to come to the UK?
Oxford And Cambridge Compared On COVID-19
In Oxford And Cambridge Compared On COVID-19, I compared the COVID-19 rates of the two University cities.
- Oxford and Cambridge are very similar-sized cities and both ae surrounded by similar counties and countryside.
- During the pandemic, Oxford had a much higher COVID-19 rate than Cambridge.
From my experiences and observations in Cambridge, I believe that the city has a high level of coeliacs.
Why Does Cambridge Have A High Level Of Coeliacs?
I doubt, it is due to the genetics of the local population, as if it was, my coeliac disease would have been picked up earlier.
The two most likely causes are.
- Someone in the Health Authority decided to have a Whack-a-Coeliac policy.
- Addenbrooke’s Hospital, in conjunction with Cambridge University and the Sanger Centre were testing the accuracy of the newly-develop genetic test for coeliac disease.
Note.
- Both routes would have needed a streamlined endoscopy unit to test all those thought to be coeliac.
- I was tested twice in such a unit to prove that I was coeliac, after the genetic test showed, I probably was.
- Fit, younger patients were pushed to have the endoscopy without a sedative, which cut the number and cost of recovery beds and staff.
- My endoscopies were performed without a sedative, by a doctor working alone.
- I was able to drive home, a few minutes after the procedure.
It was a classic case of applying good old-fashioned time-and-motion to a test that would have to be applied to a large number of patients.
If Cambridge’s army of coeliacs helped the city take the edge of the pandemic, what would a Whack-a-Coeliac policy, do for other cities?
Appropriate Nutrient Supplementation In Coeliac Disease
The title of this post, is the same as that of this article on PubMed.
I choose this article, as the abstract gave a good list of related problems to coeliac disease.
This is the abstract.
Reduced levels of iron, folate, vitamin B12, vitamin D, zinc, and magnesium are common in untreated celiac disease (CD) patients probably due to loss of brush border proteins and enzymes needed for the absorption of these nutrients. In the majority of patients, removal of gluten from the diet leads to histological recovery and normalization of iron, vitamin, and mineral levels. Iron deficiency anemia is the most common extra-intestinal sign of CD and usually resolves with adherence to a gluten-free diet. However, deficiencies of both folate and vitamin B12 may persist in some patients on a gluten-free diet, thus requiring vitamin supplementation to improve subjective health status. Similarly, exclusion of gluten from the diet does not always normalize bone mineral density; in these cases, supplementation of vitamin D and calcium is recommended. Resolution of mucosal inflammation may not be sufficient to abrogate magnesium deficiency. Since gluten-free cereal products have a lower magnesium content as compared with gluten-containing counterparts, a magnesium-enriched diet should be encouraged in CD patients. In this article we discuss the frequency and clinical relevance of nutrient deficiency in CD and whether and when nutrient supplementation is needed.
I am coeliac and was diagnosed at fifty, by by a mixture of the suspicions of an elderly locum, the very modern genetic test and the classic endoscopic test , in the last few years of the twentieth century.
I have to admit, that being diagnosed was a bit of a surprise.
£20 Electronic Ear-Clips Train The Body To Decrease Blood Pressure
The title of this post, is the same as that of this article in The Times.
These two paragraphs outline how the device is used.
A £20 device that delivers “tingling” electric pulses to the ears and can be worn at home could be almost twice as effective as drugs at reducing blood pressure, a neuroscientist has said.
Early trials suggest that wearing the small electrodes clipped to the ears for half an hour per day over two weeks while relaxing, watching TV or eating can reduce blood pressure by up to 15mm of mercury (mm Hg), compared with 8mm Hg to 10mm Hg for drugs such as Ace inhibitors or beta-blockers.
It appears the device has been developed at University College London.
Would I Use Electronic Ear-Clips To Control My Blood Pressure?
Soon after my wife died in 2007, my cholesterol levels rose.
The Ipswich Town Physiotherapist, who was a drinking partner before matches at Portman Road, recommended that I see his dietician.
She identified the following.
- My diet had changed since my my wife’s death, as I was choosing the food and doing the cooking.
- She suspected, that I wasn’t eating enough soluble fibre.
- I was eating enough fruit and vegetables.
Her solution was two-fold.
- Swap butter and other spreads for Benecol.
- Make sure, I eat, at least one small tin of baked beans every week.
Obviously, as I had been found to be coeliac in 1997, I should stay gluten-free.
I’ve seen other dieticians since and none have criticised, what she said.
No doctor has also ever said, that there is something wrong with my cholesterol.
After my stroke in 2010, I was put on Warfarin to thin my blood.
The only addition to my cocktail of drugs, was that after an unexplained collapse, I was put on blood pressure drugs.
So to return to the question I asked at the top of this section.
I may take six or seven drugs and vitamin tablets every day, but swapping one or two for half-an-hour with an electronic device wouldn’t be too much trouble.
That is, if I could tolerate the device, as I’m not keen on headphones.
But it could be an interesting alternative to taking pharmaceutical drugs.
Council Wants To Only Serve Vegan Food At Events
The title of this post, is the same as that of this article on the BBC.
This is the sub-heading.
A West Yorkshire council will only provide vegan food at its meetings and events if a new catering plan is approved.
These three paragraphs explain the policy.
Calderdale Council wants its menus to be entirely plant-based, with a preference for seasonal and non-processed foods.
The council adopted a climate change emergency policy in 2020, which included a commitment to using plant-based catering.
Senior councillors will be asked to recommend that the vegan food scheme is adopted at a meeting on 3 June.
I am coeliac and have to eat a gluten-free diet. Sometimes, I will eat meals marked as vegan, but only after I have checked they are gluten-free.
A couple of times in my life, I have been told that I will be fine with a restaurants’s organic vegan food.
These incidents weren’t in the UK and I quickly moved on to a restaurant, which served food, that I could eat.
But you don’t know, where these sort of restrictions will lead.
- Suppose a Muslim-dominated council, insisted that all women kept their hair covered.
- Or all butcher’s shops in the area were to be closed!
- Will the local hosputal have to serve vegan food?
Any restaurant or catering facility, must serve, what its patrons want or need to eat.
Should All Hospital In-Patients Be Tested For Coeliac Disease?
I went to a medical lecture tonight and I came home on the tube with a cardiologist. As we chatted, the title of this post occurred to me.
Consider.
- A diagnosed coeliac on a gluten-free diet tends to have a stronger immune system.
- I am a diagnosed coeliac on a gluten-free diet.
- An undiagnosed coeliac tends to have a poor immune system.
- It would certainly mean, you got the right diet in hospital.
I also have some further more detailed thoughts.
My Son, George
NHS advice on those, who need to be tested for coeliac disease includes this sentence.
Testing is also recommended if you have a first-degree relative (parent, sibling or child) with coeliac disease.
When I was diagnosed as a coeliac in 1997, I told my three sons to get tested. None did!
A month or so before he did, George ended up in Trafford Park Hospital.
If they had tested him, would they have picked up his pancreatic cancer earlier?
Probably not, but it’s a question that must be asked.
Research From The University Of Padua
This paper on the US National Library of Medicine, which is from the University of Padua in Italy.
The University followed a group of 138 patients with coeliac disease, who had been on a gluten-free diet for at least six years, through the first wave of the Covid-19 pandemic in Padua.
This sentence, sums up the study.
In this analysis we report a real life “snapshot” of a cohort of CeD patients during the SARS-CoV-2 outbreak in Italy, all followed in one tertiary centre in a red area of Northern Italy. Our data show, in accordance with Emmi et al., the absolute absence of COVID-19 diagnosis in our population, although 18 subjects experienced flu-like symptoms with only one having undergone naso-pharyngeal swab.
It says that no test subject caught Covid-19, in an admittedly smallish number of patients.ost
But it reinforces my call for more research into whether if you are a diagnosed coeliac on a long-term gluten-free diet, you have an immune system, that gives you a degree of protection from the Covids.
Conditions Linked To Coeliac Disease
This page on the Coeliac UK web site is entitled Conditions Linked To Coeliac Disease, has the following subsections.
- Autoimmune Disease
- Type 1 Diabetes
- Autoimmune Thyroid Disease
- Down’s and Turner Syndrome
- Osteoporosis
- Lactose Intolerance
- Lymphoma And Small Bowel Cancer
- Autism
- Fertility
Some of the keywords are linked to other pages on the Coeliac UK web site.
Testing For Coeliac Disease
Testing for coeliac disease is not an expensive process and just involves a simple blood test, where the blood goes to the lab.
My now-retired GP reckoned in nearly all cases, the test is decisive.
Gluten Sensitivity And Epilepsy: A Systematic Review
Yesterday, The Times published this article, which was entitled ‘Game-Changing’ NHS Laser Therapy To Prevent Epileptic Seizures.
One reader had made this comment.
Be ace too if they can tweak to help migraine.
I used to suffer from something like migraine about thirty years ago. But after being found to be coeliac and going gluten-free, what ever it was seemed to disappear from my life.
Type “Coeliac Disease and Migraine” into Dr. Google and there are lots of references.
This indicates to me that serious scientists and doctors, must believe there could be a link.
There certainly is with me and going gluten-free eased my migraine-like symptoms.
I then typed “Coeliac Disease and Epilepsy” into Dr. Google and found this paper, which was entitled Gluten Sensitivity And Epilepsy: A Systematic Review.
This information is from the Abstract of the paper
Objective
The aim of this systematic review was to establish the prevalence of epilepsy in patients with coeliac disease (CD) or gluten sensitivity (GS) and vice versa and to characterise the phenomenology of the epileptic syndromes that these patients present with.
Methodology
A systematic computer-based literature search was conducted on the PubMed database. Information regarding prevalence, demographics and epilepsy phenomenology was extracted.
Results
Epilepsy is 1.8 times more prevalent in patients with CD, compared to the general population. CD is over 2 times more prevalent in patients with epilepsy compared to the general population. Further studies are necessary to assess the prevalence of GS in epilepsy. The data indicate that the prevalence of CD or GS is higher amongst particular epileptic presentations including in childhood partial epilepsy with occipital paroxysms, in adult patients with fixation off sensitivity (FOS) and in those with temporal lobe epilepsy (TLE) with hippocampal sclerosis. A particularly interesting presentation of epilepsy in the context of gluten-related disorders is a syndrome of coeliac disease, epilepsy and cerebral calcification (CEC syndrome) which is frequently described in the literature. Gluten-free diet (GFD) is effective in the management of epilepsy in 53% of cases, either reducing seizure frequency, enabling reduced doses of antiepileptic drugs or even stopping antiepileptic drugs.
Conclusion
Patients with epilepsy of unknown aetiology should be investigated for serological markers of gluten sensitivity as such patients may benefit from a GFD.
My Thoughts
These are my thoughts.
Coeliacs Prior To 1960
Consider.
- Even if my excellent GP; Doctor Egerton White, felt I was coeliac, there was no test until 1960 for coeliac disease.
- And the test that was developed using endoscopy wasn’t anywhere near to the endoscopies of the present day.
- My late wife, who was a family barrister, likened the test to child abuse on a young child.
- I have heard some terrible horror stories of doctors looking for coeliac disease in young children in the 1950s.
- But there were some successes. A friend of mine, who is in her eighties, was successfully diagnosed by her parents using food elimination. But they were both GPs.
- Recently, I’ve met two elderly ladies, who only in the last couple of years have been diagnosed as coeliacs.
Luckily, I was never tested until 1997 and I was diagnosed in 48 hours, by gene testing.
Methodology
The methodology was based on a systematic computer-based literature search of the PubMed database.
This has these advantages.
- The rules for the search can be published and peer-reviewed.
- Its Wikipedia entry says PubMed is a free database including primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics.
- The technique can surely be applied repeatedly, to see how results are changing with time.
- The search can be modified to analyse any topic, drug or condition, that appears in the PubMed database.
- The analysis could surely be applied to other databases.
As a writer of data analysis software, developing this sort of software, would be really enjoyable.
AstraZeneca Withdraws Covid Vaccine After Drop In Demand
The title of this post, is the same as that of this article on The Times.
This is the first paragraph.
AstraZeneca is withdrawing its Covid-19 vaccine worldwide, citing a “surplus of available updated vaccines” since the pandemic that target newer variants of the virus.
This was my experience of the vaccine.
I am coeliac and have a very strong immune system, as it gets all the fuel it needs.
When I had my first AZ vaccine, my immune system started to attack the chimpanzee adenovirus-based viral vector vaccine.
I felt dreadful and I’ve now been advised by doctors, not to have any more viral vector vaccines.
Interestingly, I had no reaction to the second dose, so my immune system had probably decided it was a friend.
When I had that second dose, there was all the controversy raging, about whether the AZ vaccine causes blood clots.
So I did an experiment, which I described in My INR Readings Before And After My Second AstraZeneca Jab.
I found that my INT bounced all over place, just as when a wheel hits a pothole.
Conclusion
I shall not be taking the AstraZeneca Vaccine for COVID-19 again and would think twice before allowing myself to be injected with a viral vector vaccine.
Study Highlights Increased Risk Of Second Cancers Among Breast Cancer Survivors
The title of this post, is the same as that of this news story from the Cambridge University.
This is the sub-heading.
Survivors of breast cancer are at significantly higher risk of developing second cancers, including endometrial and ovarian cancer for women and prostate cancer for men, according to new research studying data from almost 600,000 patients in England.
These are the first three paragraphs of the story.
For the first time, the research has shown that this risk is higher in people living in areas of greater socioeconomic deprivation.
Breast cancer is the most commonly diagnosed cancer in the UK. Around 56,000 people in the UK are diagnosed each year, the vast majority (over 99%) of whom are women. Improvements in earlier diagnosis and in treatments mean that five year survival rates have been increasing over time, reaching 87% by 2017 in England.
People who survive breast cancer are at risk of second primary cancer, but until now the exact risk has been unclear. Previously published research suggested that women and men who survive breast cancer are at a 24% and 27% greater risk of a non-breast second primary cancer than the wider population respectively. There have been also suggestions that second primary cancer risks differ by the age at breast cancer diagnosis.
I have a few thoughts.
The Data
The story says this about the data.
To provide more accurate estimates, a team led by researchers at the University of Cambridge analysed data from over 580,000 female and over 3,500 male breast cancer survivors diagnosed between 1995 and 2019 using the National Cancer Registration Dataset. The results of their analysis are published today in Lancet Regional Health – Europe.
A large number of cases were analysed and with these types of analysis, more is definitely better.
I would hope that this study will be repeated in a few years, when more data is available.
The Death Of My Wife
This happened to my late wife.
At about 55 in 2004, my wife developed breast cancer. Strangely, it was in the same position, where a car air-bag had bruised her breast, when it went off in an accident, a few years before.
Chemotherapy was recommended and she tried one round at home, but she couldn’t get on with it.
So she eventually had a long course of radiotherapy in Harley Street going up every day on the train. She was also doing as many court cases as she could to pay for it all.
It appeared everything had worked well and in the Autumn of 2007, she was given the all clear for the breast cancer.
But in October 2007, she was diagnosed with a squamous cell carcinoma of the heart.
She died in December 2007 at just 59.
My wife’s second cancer and her death seems to fit the pattern of the patients in the news story.
My Wife’s Genetic Background
This is rather bare, as she was adopted. Although, I do have her plaits from, when the cut them off at 18, as she’d kept them and I found them after she died.
But she didn’t come from a deprived background.
I Am Coeliac
If I have one regret, it’s that I didn’t encourage her to go gluten-free after the first cancer.
It might have boosted her immune system to help.
Conclusion
Anybody, who has breast cancer must beware a second attack of cancer.
Uf it can kill my fit 59-year-old wife, it can kill anyone.
ICE Report Shows Majority Open To Net Zero Changes
The title of this post, is the same as that of this article on The Engineer.
This is the sub-heading.
A new report has found that a majority of the UK public is amenable to the behavioural changes needed to hit the country’s net zero targets.
These two paragraphs summarise the findings of the report.
Published by the Institution of Civil Engineers (ICE) and the All-Party Parliamentary Group on Infrastructure (APPGI), the report was based on a survey of 1,000 respondents. It found that 57 per cent were open to change, with 23 per cent described as net zero enthusiasts who were likely to have already altered their behaviours, and 34 per cent wanting change, but feeling they needed further empowerment to achieve it.
However, there is far from universal agreement when it comes to behavioural change around climate action. The report found that 30 per cent of people were ‘reluctant followers’, largely acknowledging that the UK must act on emissions, but not feeling personal responsibility for that action. This segment will likely only change their behaviours if forced to do so or seeing a majority of others doing it first. Finally, 13 per cent of those surveyed were classed as ‘net zero resistors’, people who don’t believe action is necessary and have no intention of doing so.
Summing the figures up gives us.
- Net-Zero Enthusiasts – 23 %
- Wanting Change – 34 %
- Reluctant Followers – 30 %
- Net-Zero Resistors – 13 %
All politicians should be forced to read the full report.
What Would I Need To Do To Achieve a Personal Net-Zero?
My circumstances probably cover a lot of people.
- I am a widow living alone.
- My house is well-insulated with solar-panels on the roof, but heated by gas.
- I don’t have or need a car.
- I do nearly all my shopping by public transport and carry it home.
- When I go away in the UK I use trains.
- If I go to Europe, I either go or come back by train.
- I am coeliac, which means I need to eat some meat to stay healthy.
My largest carbon-emitted is probably my house, but it would be unsuitable for most current solutions.
I would put myself in the Wanting Change group, but I could move to a Net-Zero Enthusiast, if the right technology came along.
- I have seen one bolt-in electric replacement for by boiler and when the right one arrives, I’ll probably fit one.
- An affordable battery to work to with my solar panels and also allow me to use Off Peak electricity would be nice.
- As I’m coeliac, I tend to buy in the same food each week from Marks and Spencer to eat in. I might be able to cut my carbon footprint by getting Ocado to deliver. Especially, as some deliveries seem to be bike.
- If TfL decarbonised the bus, that I use most days to and from Moorgate would that lower my carbon footprint?
I suspect the largest amount of carbon outside of my house’s heating, that I’ll emit, will be tomorrow, when I take a train to Newquay.
How Do We Convert The 13 % Net-Zero Resistors?
The recent protests by French and Belgian farmers indicate, that these farmers are probably in this group. And there are other forthright groups!
The only way, that they’ll be converted, is if technology allows them to earn the same amount of money and have the same outgoings, as they do now!
The Anonymous Widower 