Did This Get Lost In The Covids?
In October 2019, I wrote Asthma Carbon Footprint ‘As Big As Eating Meat’ and it made me think, when I just read it.
I would normally follow up a post like this, but I don’t remember doing anything like that.
The Wikipedia entry for the COVID-19 pandemic in England, starts with this paragraph.
The COVID-19 pandemic was first confirmed to have spread to England with two cases among Chinese nationals staying in a hotel in York on 31 January 2020.
It looks to me, that like everybody else in England, I had the Covids on my mind.
Is Respimat A Zero-Carbon Inhaler?
Just to be sure, I asked Google AI, the question in the title of this section and received this reply.
The Respimat soft mist inhaler is considered to have virtually no associated carbon emissions from its operation because it does not contain the high global warming potential (GWP) hydrofluorocarbon (HFC) propellants found in metered-dose inhalers (pMDIs).
While it has a substantially lower carbon footprint than traditional pMDIs, it is not strictly “zero-carbon” when considering its entire life cycle, which includes manufacturing, materials (stainless steel, aluminium, polymers), and end-of-life disposal. These factors contribute a small product carbon footprint (PCF).
According to Google AI, a reusable version is available.
A reusable Respimat device has been introduced, which further reduces the carbon footprint by up to 71% over six months compared to the disposable version because the device itself is kept longer, reducing manufacturing impacts.
Google AI says this about NHS guidance.
Health bodies like the NHS encourage the use of lower-carbon inhalers like the Respimat or dry powder inhalers (DPIs) as part of their net-zero targets, provided they are clinically appropriate for the patient.
But it does seem that Respimat devices are helping to cut global warming.
What Is The Patient Experience Of Respimat?
Google AI gave this answer to my question.
Patient experience with the Respimat inhaler is generally very positive, with high satisfaction for its ease of use, handling, and the “soft mist” it produces, leading to high continuation rates in studies; patients find it easier than many older devices and report good effectiveness, though common side effects like dry mouth, cough, and sore throat can occur.
Key Aspects of Patient Experience
- High Satisfaction: Over 85-90% of patients report being satisfied or very satisfied with the Respimat’s handling and the ease of inhaling the mist.
- Preference Over Other Devices: Many patients prefer Respimat over traditional metered-dose inhalers (pMDIs) or dry powder inhalers (DPIs), finding it easier to use and more effective.
- Soft Mist Technology: Patients appreciate the gentle, slow-moving mist, which helps deliver medication effectively and feels different from a typical puff.
- Good Adherence: High satisfaction often translates to continued use, with physicians reporting high patient adherence and continuation rates after studies end.
- Improved Technique: While initial use might need guidance, pharmacist-led interventions show significant improvements in patients’ inhalation technique over time.
That doesn’t look bad to me!
Could Immunotherapy Drugs Be Delivered By An Inhaler?
We always felt the device could deliver other drugs.
Google AI gave this answer to my question.
Yes, immunotherapy drugs could potentially be delivered by an inhaler, and this approach is a promising area of active research and development, particularly for treating lung cancer and respiratory diseases like asthma.
Rationale and Research
- Targeted Treatment: Inhaled delivery allows for high concentrations of the drug to be delivered directly to the lungs, which is particularly beneficial for treating lung-specific conditions like lung cancer or severe asthma. This localized approach aims to maximize the therapeutic effect where needed.
- Reduced Side Effects: By concentrating the medication in the lungs and minimizing its systemic absorption into the bloodstream, researchers hope to significantly reduce the severe side effects (e.g., systemic toxicity, autoimmune reactions) commonly associated with traditional intravenous or oral administration of some immunotherapies and chemotherapies.
- Patient Convenience: Inhalation is a non-invasive administration route, which is more convenient and comfortable for patients compared to injections or intravenous infusions, potentially allowing for self-administration and improving patient compliance.
The Soft Mist Technology could surely be a help!
Was Osborne Reynolds The Greatest Fluid Dynamicist?
I have to ask Google AI this question, as some of the discussions that led to creation of Respimat, took place in my house at Debach, where Osborne Reynolds had lived.
Google AI gave this answer to my question.
Osborne Reynolds is considered one of the most influential and foundational contributors to the field of fluid dynamics, though naming a single person the “greatest” is subjective. His work fundamentally shaped modern engineering and physics and remains central to the study of fluid flow today.
Key Contributions to Fluid Dynamics
Reynolds’ most significant achievements include:
- The Reynolds Number: He identified a crucial dimensionless parameter (now named the Reynolds number) that determines whether fluid flow is laminar (smooth and orderly) or turbulent (chaotic and eddying). This number is a foundational concept used across all engineering and physical sciences.
- The Theory of Turbulence: In an 1895 paper, he established the standard mathematical framework used in the study of turbulence, introducing what is known as the Reynolds-averaged Navier–Stokes equations.
- Experimental Validation: His elegant, yet simple, dye experiments visually demonstrated the transition between flow regimes, providing clear empirical evidence for his theories.
- Theory of Lubrication: He developed the Reynolds equation in 1886, which still underpins the analysis of hydrodynamic lubrication in modern bearings.
- Heat Transfer and Similitude: His research into heat transfer between solids and fluids led to significant improvements in boiler and condenser designs, and his work on hydraulic similitude enables engineers to use scaled-down models (e.g., in wind tunnels for aircraft design) to predict the performance of full-scale machines.
How Many Good Ideas Did The Covids Delay?
It could be that the roll-out of Respimat for was delayed by the Covids!
But it wouldn’t have been the only idea to have been delayed in that way!
Does Injecting Disinfectant Cure Covid?
I wrote this post to test one of Trump’s most famous pieces of advice.
I asked the question of Google AI and received this answer.
No, injecting disinfectant does not cure COVID-19 and is extremely dangerous, potentially lethal. The idea is a harmful myth that was widely debunked by medical and scientific experts during the pandemic.
The language is fairly clear too.
Deadly ‘Climate Change’ Fungus Targeted In Drug Project
The title of this post, is the same as that of this article in The Times.
This is the sub-heading.
Dundee University team leading fight against Candida auris, a type of yeast that causes severe illness and spreads easily among hospital and care home patients.
These are the first two paragraphs.
A rapidly growing deadly fungus, thought to have emerged in humans due to climate change, is one of the targets of a £17.9 million drug project.
Candida auris is a type of yeast that can cause severe illness and spreads easily among patients in healthcare facilities. It was first seen in Japan in 2009 and has spread worldwide, with outbreaks in hospitals in the UK, South Africa, India and parts of North and South America.
These are points from the rest of a must-read article.
- The first cases in the UK were recorded in 2014 and numbers have been rising yearly since 2020.
- Found particularly in hospitals and care homes.
- Many infections occur when medical devices such as catheters or ventilators are fitted to patients.
- I’ve had my fill of catheters, when I had my stroke in Hong Kong.
- Immunocompromised people are most at risk.
I may be coeliac, but I tend to believe my immune system is like a platoon of SAS soldiers on steroids. It certainly gave the AstraZeneca viral vector Covid-19 vaccine a good kicking. But it welcomed the second dose, like a long-lost friend.
I asked Google if there was any interaction and got this reply.
While Candida auris is a serious fungal infection, it is not directly linked to celiac disease. However, Candida albicans, another type of yeast, has been implicated in the development or exacerbation of celiac disease through mechanisms like cross-reactivity and molecular mimicry.
I shall act responsibly and hope for the best.
But.
- Research at the University of Padua has shown, that diagnosed coeliacs sticking to their gluten-free diet, don’t get serious doses of Covid-19.
- Research at the University of Nottingham has shown, that diagnosed coeliacs sticking to their gluten-free diet, have a lower cancer rate, than the general population.
- I’ve very rarely had colds, flu and other infection, since my diagnosis as a coeliac and going gluten-free in 1997.
- I’ve never had Covid-19.
A Floridian restauranteur once called me one of the Devil’s children, as I was a coeliac. If that is true, she certainly looks after her own!
Are Zero- And Low-Alcohol Beers Cutting Road Accidents?
In The Times today, there is an article, which is entitled Drink-Driving ‘Effectively Legalised’ As Number Of Breath Tests Falls, where these are the first three paragraphs.
Drink-driving has effectively been legalised due to plummeting rates of breathalyser tests and light punishments for offenders, campaigners have warned.
The number of breath tests conducted by police has fallen by more than 62 per cent over the past decade as dangerously inebriated drivers receive short bans.
In 2009, police carried out 647,380 breath tests, but by 2023, that figure had fallen to just 240,322.
This later paragraph, adds a few more statistics.
In 2002, 18 per cent of breath tests were positive, compared to 16 per cent in 2023, while the number of drivers prosecuted for drink-driving offences has significantly decreased. Convictions for drink-driving fell from 55,300 in 2012 to 40,292 in 2023, coinciding with the sharp decline in breath testing.
Note, that in both extracts the latest comparison date is 2023, whereas the earliest date is 2009 and 2002.
This analysis is not the full picture, as there are two big differences between drinking in 2002 or 2009 and 2023.
The first difference is that 2002 and 2009 are pre-Covid, but 2023 is post-Covid.
So did Covid alter our drinking habits, which could have perhaps meant more people drank at home?
The second difference is that in 2023, zero and low alcohol beer was readily available.
I don’t drive, after a stroke ruined my eyesight, but I do drink up to four bottles a day of 0.5 % real ale. The beer I drink has been regularly available since 2017.
I wonder how many nominated drivers are now drinking these beers?
A serious survey and analysis needs to be done.
I’m Getting Fed Up Being Coeliac
I’m not getting fed up with the benefits.
- The inability to get serious doses of the covids, as was shown by the University of Padua and I documented in Risk Of COVID-19 In Celiac Disease Patients.
- The lower rate of cancer, compared to the general population as has been shown by Nottingham University.
- Coeliac diease and the B12 injections I take, indirectly helped my recovery from the stroke I had. But that was just luck!
I haven’t had a dose of the covids, but I have had all my vaccinations.
But increasingly, restaurant chains like Carluccio’s and Le Pain Quoitidien are closing only to be replaced by chains that don’t even pay lip-service to coeliacs.
Some chains, even treat being gluten-free as a fad. That is an insult to people like me and the doctors and other medical staff, who diagnosed us.
I’m getting feed up as more and more vcoeliac-friendly cafes and restaurants close.
Coeliac disease indirectly killed my son and probably my paternal grandfather and is present in at least 1-in-100 of the UK population.
We should identify all of those, who have the genes, using the genetic test, which is only a simple blood test costing a few pounds.
How To Protect The UK Population From Future Pandemics
The Times today has an article, which is entitled Flu Jab: Single-Shot Vaccine ‘Within Five Years’ Could Stop Future Pandemic.
This is the introductory paragraph of The Times article.
A single-shot vaccine against flu that would provide a lifetime of protection even against future mutations could be available in “five years or less”, scientists have said after making a breakthrough.
The article is very much a must-read, but I believe if used alongside a simple proven medical test, it could be even more effective.
Since 1997, when I was diagnosed as coeliac and started eating gluten-free food exclusively, I have never had a dose of flu.
I may have had one very mild dose of Covid-19, but I have never had a serious dose.
Research At The University Of Padua
This partial immunity to Covid-19 has been shown in a peer-reviewed scientific paper, by the University of Padua in Italy.
I discuss the Padua research in Risk Of COVID-19 In Celiac Disease Patients.
Mathematical Modelling Of Pandemics
As a control engineer, mathematical modeller and statistician, I believe that our herd immunity to future pandemics could be increased, if all new entries to the UK population, like babies and migrants, were tested for coeliac disease.
These days the coeliac test is just a blood test, that costs just a few pounds and I believe that a high percentage of gluten-free coeliacs in the UK population, because of their low susceptibility to flu pandemics, would slow the spread of the pandemic.
In a nuclear reactor non-radioactive carbon rods are often used to control the speed of the reaction.
I believe that non-susceptible coeliacs on gluten-free diets would perform the same function in the UK population.
Should Diagnosed Coeliacs Be Forced To Be Gluten-Free?
I would not force coeliacs to go gluten-free.
They would have to face up to the consequences, if they didn’t.
My son was an undiagnosed coeliac, who refused to get tested.
He died at 37 of pancreatic cancer, as his immune system was useless.
Coeliac disease and a gluten-free diet is a good wingman, but undiagnosed it can kill you!
Why Should Migrants Be Tested?
I hope they are, as some might have something nasty.
But if everyone was tested for a wide range of health and genetic conditions, could it act as a deterrent to come to the UK?
Oxford And Cambridge Compared On COVID-19
In Oxford And Cambridge Compared On COVID-19, I compared the COVID-19 rates of the two University cities.
- Oxford and Cambridge are very similar-sized cities and both ae surrounded by similar counties and countryside.
- During the pandemic, Oxford had a much higher COVID-19 rate than Cambridge.
From my experiences and observations in Cambridge, I believe that the city has a high level of coeliacs.
Why Does Cambridge Have A High Level Of Coeliacs?
I doubt, it is due to the genetics of the local population, as if it was, my coeliac disease would have been picked up earlier.
The two most likely causes are.
- Someone in the Health Authority decided to have a Whack-a-Coeliac policy.
- Addenbrooke’s Hospital, in conjunction with Cambridge University and the Sanger Centre were testing the accuracy of the newly-develop genetic test for coeliac disease.
Note.
- Both routes would have needed a streamlined endoscopy unit to test all those thought to be coeliac.
- I was tested twice in such a unit to prove that I was coeliac, after the genetic test showed, I probably was.
- Fit, younger patients were pushed to have the endoscopy without a sedative, which cut the number and cost of recovery beds and staff.
- My endoscopies were performed without a sedative, by a doctor working alone.
- I was able to drive home, a few minutes after the procedure.
It was a classic case of applying good old-fashioned time-and-motion to a test that would have to be applied to a large number of patients.
If Cambridge’s army of coeliacs helped the city take the edge of the pandemic, what would a Whack-a-Coeliac policy, do for other cities?
AstraZeneca Withdraws Covid Vaccine After Drop In Demand
The title of this post, is the same as that of this article on The Times.
This is the first paragraph.
AstraZeneca is withdrawing its Covid-19 vaccine worldwide, citing a “surplus of available updated vaccines” since the pandemic that target newer variants of the virus.
This was my experience of the vaccine.
I am coeliac and have a very strong immune system, as it gets all the fuel it needs.
When I had my first AZ vaccine, my immune system started to attack the chimpanzee adenovirus-based viral vector vaccine.
I felt dreadful and I’ve now been advised by doctors, not to have any more viral vector vaccines.
Interestingly, I had no reaction to the second dose, so my immune system had probably decided it was a friend.
When I had that second dose, there was all the controversy raging, about whether the AZ vaccine causes blood clots.
So I did an experiment, which I described in My INR Readings Before And After My Second AstraZeneca Jab.
I found that my INT bounced all over place, just as when a wheel hits a pothole.
Conclusion
I shall not be taking the AstraZeneca Vaccine for COVID-19 again and would think twice before allowing myself to be injected with a viral vector vaccine.
British Five-Year-Olds Up To 7cm Shorter Than Western Peers
The title of this post, is the same as that of this article in The Times.
This is the sub-heading.
Poor diet and health service cuts blamed for ‘pretty startling’ trend
These are the first two paragraphs.
Five-year-olds in Britain are on average up to seven centimetres shorter than their peers in other wealthy nations, in a trend described as “pretty startling”.
A poor national diet has been highlighted as a major culprit in Britain’s fall down international rankings of child height.
I am coeliac and am only 170 cm.
During the pandemic, I did some statistical research on coeliac disease and the covids for my own interest.
I found a peer-reviewed Indian medical paper entitled Coeliac Disease: Can We Avert The Impending Epidemic In India? The author felt that modern high-gluten wheats, were increasing the rate of the disease.
The author also said this about introduction gluten to babies in Sweden.
The time of first exposure to wheat influences the development of celiac disease. In countries such as Finland, Estonia, and Denmark, characterized by low gluten consumption in infancy, celiac disease prevalence is much lower than in Sweden where gluten consumption is high in infancy. A natural experiment occurred in Sweden about two decades ago when national recommendations were made to introduce wheat into the diet after cessation of breast feeding at six months. This change was coupled with increased wheat gluten consumption through infant feeds. Together these measures resulted in a two-fold increase in incidence of celiac disease in Sweden, which was attributed to introduction of wheat into the diet after cessation of breast feeding. In 1996 this recommendation was changed to introduce gluten in gradually increasing amounts while the infant was still being breast fed. This led to a dramatic decrease in celiac disease incidence.
It is interesting to look at heights of five-year-olds given in the Times article for the four countries.
- Denmark – 117.4 – 118.1
- Estonia – 116.9 – 115.7
- Finland – 116.3 – 114.5
- Sweden – 115.1 – 115.1
Note that all heights are in centimetres, with boys first.
As according to the graphs in the article the UK and the US have shown the biggest declines in height, is gluten-rich junk food, the major cause of this decline?
More research needs to be done!
Coeliac Journey Through Covid-19 – Should Newborns Be Tested For Coeliac Disease?
Should Newborns Be Tested For Coeliac Disease?
This article on the BBC is entitled Newborns To Get Rapid Genetic Disease Diagnosis.
This is the sub-heading.
Rare genetic disorders will be diagnosed and treated in babies thanks to a project to sequence the complete DNA of 100,000 newborns.
These are the first four paragraphs.
It should spare hundreds of families in England months, or years, of anguish waiting to find out why their children are ill.
The project is the first time that whole genome sequencing (WGS) has been offered to healthy babies in the NHS.
It will screen for around 200 disorders, all of them treatable.
The Newborn Genomes Programme, to begin next year, is thought to be the biggest study of its kind in the world. If successful, it could be rolled out across the country.
- My family have suffered greatly because of coeliac disease, as I related in Coeliac Journey Through Covid-19 – The Pain Of Coeliac Disease.
- Coeliac disease affects at least 1-in-100 of the UK population.
- The test is not difficult to perform.
I believe that for these reasons, coeliac disease must be one of the diseases that are tested for in the Newborn Genomes Programme.
Coeliac Journey Through Covid-19 – A Whack-A-Coeliac Policy
A Whack-A-Coeliac Policy
Note that this page is an updated version of Should The NHS Adopt A Whack-A-Coeliac Policy?, which I wrote in July 2020.
Because of the high number of diagnosed coeliacs in the Cambridge area, I believe that I was diagnosed to be coeliac, by possible use of a Whack-a-Coeliac policy at Addenbrookes Hospital in Cambridge, in the last years of the Twentieth Century.
- I was suffering from low B12 levels and my GP sent me to the hospital to see a consultant.
- It was only a quick visit and all I remember, is the speed with which the nurse took my blood.
- A couple of days later, I received a letter from the hospital, saying it was likely I was a coeliac and it would be confirmed by an endoscopy.
- A point to note, is that I had my endoscopy with just a throat spray and this must have increased the efficiency and throughput and reduced the cost of the procedure.
The only way, I could have been diagnosed so quickly would have been through an analysis of my genes and blood. But I was never told, what method was used.
I have a few further thoughts.
My Health Since Diagnosis
It has undoubtedly improved.
Cancer And Diagnosed Coeliacs On A Gluten-Free Diet
Joe West of Nottingham University has shown, that diagnosed coeliacs on a gluten-free diet have a 25% lower risk of cancer compared to the general population.
That is certainly a collateral benefit of being a coeliac. But is it being a coeliac or the diet?
I’m no medic, but could the reason be, that diagnosed coeliacs on a gluten-free diet have a strong immune system?
Coeliac Disease Is A Many-Headed Hydra
I have heard a doctor describe coeliac disease or gluten-sensitivity as a many-headed hydra, as it can turn up in so many other illnesses.
Type “coeliac disease many-headed hydra” into Google and this article on the NCBI , which is entitled Gluten Sensitivity: A Many Headed Hydra, is the first of many.
This is the sub-title of the article.
Heightened responsiveness to gluten is not confined to the gut
My son; George was an undiagnosed coeliac, who had a poor diet consisting mostly of Subways, cigarettes and high-strength cannabis. He died at just thirty-seven of pancreatic cancer.
Did George have a poor immune system, which was useless at fighting the cancer?
Undiagnosed Coeliac Disease In The Over-Sixty-Fives
In A Thought On Deaths Of The Elderly From Covid-19, I used data from Age UK and Coeliac UK to estimate the number of coeliacs in the UK over the age of sixty-five. I said this.
Age UK has a figure of twelve million who are over 65 in the UK. If 1-in-100 in the UK are coeliac, that is 120,000 coeliacs over 65.
But some research shows that the number of coeliacs can be as high as 1-in-50.
If that 120,000 were all diagnosed, I would have several coeliacs amongst my over-65 friends. I have just one and she is self-diagnosed.
Are all these undiagnosed coeliacs out there, easy targets for diseases like cancer and COVID-19?
The Ease Of Testing For Coeliac Disease
I was worried that my granddaughter was coeliac and I asked my GP, how difficult a test is to perform.
He said, that a genetic test is usually quick and correct and only a few borderline cases need to be referred to a consultant.
Diagnosis has moved on a lot in twenty years.
Cambridge, Oxford and Covid-19
Six weeks ago I wrote Oxford And Cambridge Compared On COVID-19, to try to find out why the number of Covid-19 cases are so much lower in Cambridge than Oxford.
Checking today, the rate of lab-confirmed cases of COVID-19 per 100,000 residents is as follows.
- Cambridge 336.6
- Oxford 449
So why the difference?
In the related post, this was my explanation.
Is the large number of diagnosed coeliacs around Cambridge, the reason the area has a lower COVID-19 rate than Oxford?
It sounds a long shot, but it could be a vindication of a possible Whack-a-Coeliac policy at Addenbrooke’s in the last years of the Twentieth Century.
Or were the hospital testing the genetic test for coeliac disease? Perhaps, in conjunction with Cambridge University and/or the Sanger Centre.
Conclusion
I believe the NHS should seriously look at a Whack-a-Coeliac policy!
- The health of a large number of people would improve.
- There would be less cancer in the UK.
- A better combined National Immune System might help in our fight against the next virus to follow COVID-19.
It would be a very simple testing program, that would be mainly in the hands of the GPs, their nurses and the testing laboratories.
The Anonymous Widower 