Covid: Hackney Railway Arch Rave Attended By ‘300 People’
The title of this post, is the same as that of this article on the BBC.
This is the introductory paragraphs.
Police have issued more than £15,000 in fines after 300 people attended an illegal rave in a railway arch.
Officers raided an unlicensed music event in Nursery Road, Hackney, at 01.30 GMT on Sunday.
Sounds to me, that the safest way to handle this number of ravers, is to use a water cannon, firing smart water, so they can be identified for a couple of weeks.
Coronavirus: Why Combining The Oxford Vaccine With Russia’s Sputnik V Vaccine Could Make It More Effective
The title of this post is the same as that of this article on The Conversation.
The Oxford–AstraZeneca COVID-19 Vaccine
This paragraph from the Wikipedia entry for the Oxford–AstraZeneca COVID-19 vaccine, gives the basic details of the vaccine.
The Oxford–AstraZeneca COVID-19 vaccine (codenamed AZD1222) is a COVID-19 vaccine developed by Oxford University and AstraZeneca given by intramuscular injection, using as a vector the modified chimpanzee adenovirus ChAdOx1. One dosing regimen showed 90% efficiency when a half-dose was followed by a full-dose after at least one month, based on mixed trials with no participants over 55 years old. Another dosing regimen showed 62% efficiency when given as two full doses separated by at least one month.
It puzzles me and I suspect it puzzles experts, that the two different vaccination regimes gave different answers.
The article on the Conversation says this.
This was intriguing. Why would giving people less of the vaccine lead to a more effective immune response? The answer to this may lie in the design of the vaccine, and could mean that there are ways to make this vaccine – and others that use the same design – more effective.
I will attempt to answer this question, in the rest of this post.
The Russian Sputnik V Vaccine
This paragraph from the Wikipedia entry for the Oxford–Russian Sputnik V vaccine, gives the basic details of the vaccine.
Gam-COVID-Vac, trade-named Sputnik V, is a COVID-19 vaccine developed by the Gamaleya Research Institute of Epidemiology and Microbiology, and registered on 11 August 2020 by the Russian Ministry of Health.
In most countries following guidelines of the World Health Organization, vaccine candidates are not approved for regular use until safety and efficacy data from Phase III trials are assessed and confirmed internationally by regulators. Gam-COVID-Vac was initially approved for distribution in Russia on the preliminary results of Phase I-II studies eventually published on 4 September 2020.
The quick approval of Gam-COVID-Vac was met with criticism in mass media and precipitated discussions in the scientific community whether this decision was justified in the absence of robust scientific research confirming the safety and efficacy of the vaccine.
In December 2020, interim analysis from 22,714 participants in a Phase III trial were published, claiming 91% efficacy with no unusual side effects.
Wikipedia says, that a medical citation is needed for the Phase III trial.
Both Vaccines Are Viral-Vector Vaccines
The Oxford vaccine is based around a modified chimpanzee adenovirus ChAdOx1, whilst the Russian vaccine is based on two human adenoviruses.
Adenoviruses are a family of viruses, that include the common cold.
The two shots of the Oxford vaccine are identical in composition, but the two shots of the Russian vaccine use a different adenovirus.
Both vaccines are what is known as viral vector vaccines.
Both vaccines would appear to deliver the same details of the spike protein of the virus to prime the body’s immune system to fight the real virus.
A Possible Problem With Viral-Vector Vaccines
This is a paragraph from the article on the Conversation, which talks of a problem with viral-vector vaccines.
When a person is given a viral-vector vaccine, as well as generating an immune response against the coronavirus’s spike protein, the immune system will also mount a response against the viral vector itself. This immune response may then destroy some of the booster dose when it is subsequently delivered, before it can have an effect. This has long been recognised as a problem.
It looks like a case of shoot the messenger to me.
The Russian Solution To The Problem
The Russian vaccine appears to get round the problem, by using two different adenoviruses in their two shots. There are fifty adenoviruses that affect humans, so they have a wide choice.
The first shot would only prime the immune system to the spike protein and one adenovirus, which could mean that the second and different adenovirus gets through without being attacked.
Co-Operation Between AstraZeneca And The Russians
This is the last sentence from the article on the Conversation.
This has now led to AstraZeneca testing a new hybrid vaccine schedule, comprising one dose of its vaccine and one of the Ad26-vector Sputnik V, to see if this makes the Oxford/AstraZeneca vaccine more effective.
I like the thinking behind this idea.
The priming for the immune system gets delivered by two totally unrelated delivery systems.
Conclusion
I wouldn’t be surprised to see this type of hybrid vaccine developed.
Surely, if we need to vaccinate every year against an ongoing Covid-19 threat, eventually, a succession of viral-vectors can be developed to fool the immune system.
The negotiation with the Russians could be tricky.
Covid-19: Two £10,000 Fines For ‘150-Person’ Funeral
The title of this post, is the same as that of this article on the BBC.
This is the introductory paragraph.
A funeral director has been fined £10,000 after police were called to a funeral with close to 150 people in attendance.
This time, it appears that the covidiots were Roman Catholics.
Covid: 400-Person Wedding Party In Stamford Hill Broken Up By Police
The title of this post, is the same as that of this article on the BBC,
I would have thought, that the organisers would have known better, as the Jewish community in Stamford Hill has suffered badly from th covids.
In Jews In The UK And COVID-19, which I wrote in May 2020, I did a simple analysis and said this.
From these simple figures Jews are over three times more likely to die of COVID-19, than the general population.
Walk around the area and their are signs up in Hebrew telling people to Stay Safe.
How can people be so stupid?
But that’s religion for you!
A Measles Epidemic
About a year ago, I was asked by my GP, if I had been vaccinated against measles.
I said no, but I have did have a bad case at about twenty-five, which I recounted in A Surprising Question From A Doctor.
He said fine and then added that there’s a measles epidemic in the North of the borough.
Apparently, the ultra-Orthodox Jews don’t have a high level of vaccination and a lot of children.
This worries me, as will they bother to get the vaccine for the covids.
They should listen to the eminently sensible Chief Rabbi.
Chaos In The Balls Pond Road
This article in The Times is called High Court Deals Blow To Expansion Of Cycle Lanes And Wider Pavements.
This was the first paragraph.
Road closures designed to boost walking and cycling could face legal challenges after a judge declared that a big expansion of the plans was “unlawful”.
A challenge to the often ill-thought out improvements from black-cab drovers has been successful.
My experience, yesterday, summed up my inconvenience with such a scheme.
yaxiI actually, think that matters are being made worse by some of the designs and planning by the Council Clowns.
A big scheme is being undertaken around the Balls Pond Road to bring in a cycleway between Tottenham and the City. In Hackney, it looks like it will improve walking and calm the traffic in residential areas as well.
I had a serious stroke ten years and my eyesight was ruined enough, so that I couldn’t drive, so I rely heavily on buses to get around.
On Tuesday, I needed to go to the Angel to pick up a prescription. On arriving at the junction of Balls Pond Road and Southgate Road, I found that one of Islington’s Idiots had planned to dig up the junction and all four bus stops were closed. The traffic was so jammed as well, that there weren’t even any stray black cabs stoating about!
In the end, I walked to the next bus stop. This was not easy, as the lock-down has ruined my feet and they were painful.
But I got a bus to the Angel and after a bit of food shopping, I looked for a taxi to come home.
But another branch of Clowns and Idiots Ltd. has closed the taxi rank, so I had to resort to the bus, which got stuck in another set of jams caused by Thames Water at one of their well-used Party Places.
I did find a black cab, but he was unable to take me home, as the area was gridlocked. So he said give him a tenner and walk. As this was less than what was on the meter, I complied!
I laid down the principles of project planning using small computers in the 1970s.
Obviously, My ideas have fallen on deaf ears in Islington Council.
Corporate Funding In Battery Storage In 2020 Was Up By 136% Compared To 2019, Mercom Says
The title of this post, is the same as that of this article on Energy Storage News.
This is a paragraph, which sums up funding worldwide.
The amount of corporate funding coming into the global battery storage industry in 2020 was more than double the amount the previous year, with over US$6.5 billion raised last year compared to around US$2.8 billion in 2019.
It appears that serious money is increasingly going into energy storage.
Some very big deals involving hundreds of millions of dollars are detailed, in countries as varied as Sweden, Taiwan, the UK and the US.
Particular mention is given to a Swedish battery battery design and manufacturing start-up called Northvolt, who raised $600 million.
Most seem to be based on lithium-ion batteries, so the future could be bright for start-up companies like Cornish Lithium!
Covid: Biden Vows 100m Vaccinations For US In First 100 Days
The title of this post, is the same as that of this article on the BBC.
These are the introductory paragraphs of the article.
US President-elect Joe Biden has set a goal of 100 million Covid vaccinations in his first 100 days in office.
He said his first months in office would not end the outbreak and gave few details on a rollout plan but he said he would change the course of Covid-19.
Introducing his health team for when he takes office on 20 January, he urged Americans to “mask up for 100 days”.
I can see a few rocks ahead in his plan.
Vaccine Production
According to media reports, the number of vaccinations has declined since Friday because of delivery issues with the Pfizer vaccine.
In Tracking COVID-19 Vaccination Statistics, the number of vaccinations in the last few days are as follows.
- 15th January – 324233
- 16th January – 549920
- 17th January – 205235
- 18th January – 204076
The figures have been declining because of these delivery issues.
Pfizer say they are updating the factory in Belgium to increase production.
I don’t believe that, as the United States will be needing a million does per day, that they can get enough production on a reliable basis.
A Federal Lockdown
I believe that to get the virus under control in the United States, the country must follow the route of countries like France, Germany, Japan, South Korea and the UK and have a period of perhaps a hundred days of total lockdown.
But I doubt that would be possible in the United States.
Mask Wearing
I don’t believe that Americans will mask up for a hundred days.
The Anti-Vaxxers And The Trumpeteers
I can see them having a field day!
Especially, if Joe Biden adds some strong legislation to curb the spread of the virus. Which in my view is needed.
Conclusion
It’s going to get a lot messier and probably more dangerous in the United States in the next few months.
Shell Withdraws From Waste To Jet Fuel Plant Project
The title of this post, is the same as that, of this article on Insider Media.
This is the introductory paragraph.
Oil giant Shell has withdrawn from the joint development agreement for a proposed facility for the conversion of waste into aviation fuel.
It would appear that the Altalto project will continue and has no likelihood of folding in the near future.
I like the idea behind Altalto, which will take household and industrial waste and turn it into sustainable aviation fuel and biodiesel.
But I also like Shell’s Blue Hydrogen Process, which takes methane and effectively removes the carbon to create carbon-neutral hydrogen.
Conclusion
I feel the world is a big enough place for both technologies.
The Diamond Light Source And Malaria
I had to put a link to this page on the Diamond Light Source web site, which is entitled Malaria in Action.
This is the introductory paragraph.
In 2007 Helen Saibil was at a conference in Australia. Amongst the presentations there happened to be talks on the parasites malaria and toxoplasma and how they infect mammalian cells, causing disease. Helen is a structural biologist and whilst listening she began to realise that her newly acquired skills -she was doing electron tomography of cells- might allow the researchers to see things they had never seen before.
The page describes the work of the Diamond Light Source to understand and lead the might against malaria.
The Anonymous Widower 